Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease
Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease
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DOI：
10.1016/j.parkreldis.2014.01.003
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发表时间：
2014-04-01
影响因子：
4.1
通讯作者：
Sobue, Gen
中科院分区：
文献类型：
--
作者：
Nakamura, Tomohiko;Hirayama, Masaaki;Sobue, Gen
目的：心脏交感神经去支配与帕金森病（PD）的体位性低血压（OH）有关，然而，心脏交感神经的生理作用尚未阐明。为了阐明心脏在直立性应激中的作用，我们评估了心脏交感神经是否可以改变心脏活动和收缩压（BP）与总外周阻力的升高或降低在头高位倾斜test.Methods：95例PD患者和17例正常对照组。在直立倾斜试验中，我们使用心阻抗描记法测量总外周阻力、每搏输出量、心率和收缩压。心脏去神经被定义为心脏与纵隔的比率
Purpose: Cardiac sympathetic denervation is associated with orthostatic hypotension (OH) in Parkinson's disease (PD); however, the physiological role of cardiac sympathetic nerves has yet to be elucidated. To clarify the role of the heart in orthostatic stress, we evaluated whether cardiac sympathetic nerves can alter cardiac activity and systolic blood pressure (BP) in association with elevations or depressions of total peripheral resistance during the head-up tilt test.Methods: Ninety-five PD patients and 17 normal controls were enrolled. Using impedance cardiography, we measured total peripheral resistance, stroke volume, heart rate, and systolic BP during the head-up tilt test. Cardiac denervation was defined as a heart-to-mediastinum ratio