Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings
Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings
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DOI：
10.1097/00004583-200403000-00016
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发表时间：
2004-03-01
影响因子：
13.3
通讯作者：
van Engeland, H
中科院分区：
文献类型：
--
作者：
Durston, S;Pol, HEH;van Engeland, H
目的：研究注意缺陷/多动障碍（ADHD）家族风险增加对脑形态学的影响。方法：对30名患有ADHD的男孩、30名未患ADHD的兄弟姐妹和30名匹配的对照组进行了基于全脑磁共振成像扫描的脑容量测量。结果：患有ADHD的受试者及其未受影响的兄弟姐妹显示右侧前额叶灰质和左侧枕叶灰质和白质减少高达9.1% （p < 0.05）。ADHD患者的右小脑体积减少了4.9% (p = 0.026)，而未受影响的兄弟姐妹则没有减少（p = 0.308）。ADHD患者颅内容积减少4.0% (p = 0.031)，而未受影响的兄弟姐妹颅内容积也有下降趋势（p = 0.068）。结论：ADHD患者的大脑皮层灰质和白质体积减少在其未受影响的兄弟姐妹中也存在，这表明他们与该疾病的家族风险增加有关。相比之下，兄弟姐妹的小脑没有受到影响，这表明在ADHD患者中观察到的体积减少可能与这种疾病的病理生理更直接相关。
Objective: To study the influence of increased familial risk for attention-deficit/hyperactivity disorder (ADHD) on brain morphology. Method: Volumetric cerebral measures based on whole brain magnetic resonance imaging scans from 30 boys with ADHD, 30 of their unaffected siblings, and 30 matched controls were compared. Results: Both subjects with ADHD and their unaffected siblings displayed reductions in right prefrontal gray matter and left occipital gray and white matter of up to 9.1% (p < .05). Right cerebellar volume was reduced by 4.9% in subjects with ADHD (p = .026) but not in their unaffected siblings (p = .308). A 4.0% reduction in intracranial volume was found in subjects with ADHD (p = .031), while a trend was observed in their unaffected siblings (p = .068). Conclusions: The volumetric reductions in cortical gray and white matter in subjects with ADHD are also present in their unaffected siblings, suggesting that they are related to an increased familial risk for the disorder. In contrast, the cerebellum is unaffected in siblings, suggesting that the reduction in volume observed in subjects with ADHD may be more directly related to the pathophysiology of this disorder.