Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis
Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis
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胃癌中抑癌基因QKI的下调及其对癌症预后的影响
DOI：
10.1016/j.bbrc.2012.04.138
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发表时间：
2012-05-25
影响因子：
3.1
通讯作者：
Lu, Zifan
中科院分区：
文献类型：
--
作者：
Bian, Yongqian;Wang, Li;Lu, Zifan
胃癌（GC）是全球第四大常见癌症，也是癌症相关死亡的第二大原因。 RNA 结合蛋白 Quaking (QKI) 是一种新发现的多种癌症中的肿瘤抑制因子，但其在 GC 中的作用尚不清楚。我们的研究旨在阐明QKI表达与GC临床病理特征和预后的关系。在222例GC患者的标本中，发现大多数GC组织中QKI表达显着降低，这很大程度上是由于启动子高甲基化所致。体外研究中QKI过表达降低了GC细胞系的增殖能力。此外，QKI表达降低与分化状态差、浸润深度、胃淋巴结转移、远处转移、晚期TNM分期和生存率差密切相关。多变量分析显示 QKI 表达是患者生存的独立预后因素。 (C) 2012 Elsevier Inc. 保留所有权利。
Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients' specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival. (C) 2012 Elsevier Inc. All rights reserved.