FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
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DOI：
10.1016/s0014-5793(04)00287-x
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发表时间：
2004-04-23
期刊：
影响因子：
3.5
通讯作者：
Schlessinger, J
中科院分区：
文献类型：
--
作者：
Gotoh, N;Laks, S;Schlessinger, J
FRS2α和FRS2β是FRS2停靠蛋白家族的两个成员，在纤维母细胞生长因子(FGF)或神经生长因子(NGF)刺激下，酪氨酸被磷酸化。酪氨酸磷酸化的FRS2α是一个募集多种信号蛋白的平台，用于激活RAS丝裂原激活蛋白(MAP)信号转导通路。我们报道了Frs2pha和Frs2beta在小鼠胚胎中具有不同的时空表达模式。我们进一步证明，当FRS2beta在Frs2pha(-/-)小鼠胚胎的成纤维细胞中表达时，可以补偿FRS2pha因激活MAP激酶而失去的FRS2pha。我们认为，FRS2家族蛋白通过激活包括MAP激酶在内的常见信号蛋白在体内具有不同的作用。(C)2004年欧洲生化学会联合会。爱思唯尔出版，版权所有。
FRS2alpha and FRS2beta, two members of the FRS2 family of docking proteins, become tyrosine phosphorylated in response to fibroblast growth factor (FGF) or nerve growth factor (NGF) stimulation. Tyrosine phosphorylated FRS2alpha serves as a platform for the recruitment of multiple signaling proteins for activation of the Ras-mitogen-activated protein (MAP) kinase signaling cascade. We report that Frs2alpha and Frs2beta have distinct spatio-temporal expression patterns in mouse embryos. We further show that FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts from Frs2alpha(-/-) mouse embryos. We propose that the FRS2 family proteins have distinct roles in vivo through activation of common signaling proteins including MAP kinase. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.