The on-again, off-again relationship between mitochondrial genomes and species boundaries.
The on-again, off-again relationship between mitochondrial genomes and species boundaries.
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DOI：
10.1111/mec.13959
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发表时间：
2017-04
影响因子：
4.9
通讯作者：
Sharbrough J
中科院分区：
文献类型：
--
作者：
Sloan DB;Havird JC;Sharbrough J
生殖隔离和物种障碍的研究往往集中在线粒体基因组，并产生了两个替代和几乎截然相反的叙述。一方面，线粒体DNA可能处于物种形成事件的最前沿，与共同进化的线粒体相互作用负责一些最早的遗传不相容性之间出现的孤立的人群。另一方面，即使核基因流动受到限制，也有许多mtDNA跨物种渗入的情况。我们认为，这些看似矛盾的模式可能是由一个单一的根本原因。具体来说，线粒体DNA中有害突变的积累产生了两种替代进化解决方案的问题。在某些情况下，核基因组中的补偿性或上位性变化可能会改善线粒体突变的影响，从而在种群内建立共适应的线粒体基因型，并形成种群间生殖不相容性的基础。或者，具有高线粒体突变负荷的群体可以通过用更合适的外来线粒体单倍型替换来拯救。再加上许多非适应性的渐渗机制，可以优先影响细胞质基因组，这种形式的适应性渐渗可能有助于线粒体和核谱系之间的广泛不一致。在这里，我们回顾了最近的进展有关线粒体基因渗入和线粒体不相容性，包括潜在的线粒体DNA和相互作用的核基因的共渗入。我们还解决了一个新出现的争论的经典假设，选择线粒体基因组是低效的，并讨论了机制，导致谱系替代的进化路径，以应对线粒体突变的积累。
The study of reproductive isolation and species barriers frequently focuses on mitochondrial genomes and has produced two alternative and almost diametrically opposed narratives. On one hand, mtDNA may be at the forefront of speciation events, with coevolved mitonuclear interactions responsible for some of the earliest genetic incompatibilities arising among isolated populations. On the other hand, there are numerous cases of introgression of mtDNA across species boundaries even when nuclear gene flow is restricted. We argue that these seemingly contradictory patterns can result from a single underlying cause. Specifically, the accumulation of deleterious mutations in mtDNA creates a problem with two alternative evolutionary solutions. In some cases, compensatory or epistatic changes in the nuclear genome may ameliorate the effects of mitochondrial mutations, thereby establishing coadapted mitonuclear genotypes within populations and forming the basis of reproductive incompatibilities between populations. Alternatively, populations with high mitochondrial mutation loads may be rescued by replacement with a more fit, foreign mitochondrial haplotype. Coupled with many non-adaptive mechanisms of introgression that can preferentially affect cytoplasmic genomes, this form of adaptive introgression may contribute to the widespread discordance between mitochondrial and nuclear genealogies. Here, we review recent advances related to mitochondrial introgression and mitonuclear incompatibilities, including the potential for cointrogression of mtDNA and interacting nuclear genes. We also address an emerging controversy over the classic assumption that selection on mitochondrial genomes is inefficient and discuss the mechanisms that lead lineages down alternative evolutionary paths in response to mitochondrial mutation accumulation.
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影响因子：
2.4
作者：
BERNATCHEZ, L;GLEMET, H;DANZMANN, RG
通讯作者：
DANZMANN, RG
影响因子：
3.3
作者：
Burger G;Gray MW;Forget L;Lang BF
通讯作者：
Lang BF
影响因子：
3.3
作者：
Bolnick, Daniel I.;Turelli, Michael;Near, Thomas J.
通讯作者：
Near, Thomas J.
影响因子：
3.3
作者：
Arnqvist, Goran;Dowling, Damian K.;Hosken, David J.
通讯作者：
Hosken, David J.
DOI：
10.1073/pnas.85.6.1893
发表时间：
1988-03-01
影响因子：
11.1
作者：
ARNOLD, J;ASMUSSEN, MA;AVISE, JC
通讯作者：
AVISE, JC