The pathogenesis of maturity-onset diabetes mellitus: is there a link to islet amyloid polypeptide?
The pathogenesis of maturity-onset diabetes mellitus: is there a link to islet amyloid polypeptide?
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成年发病糖尿病的发病机制：与胰岛淀粉样多肽有联系吗？
DOI：
10.1002/bies.950090109
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Johnson,KH
中科院分区：
文献类型：
--
作者：
Westermark,P;Johnson,KH
本文综述了从人和猫胰岛淀粉样蛋白及人胰岛素瘤淀粉样蛋白中分离到的一种新多肽（胰岛淀粉样多肽：IAPP）的发现。在结构上，人和猫的IAPP类似于降钙素基因相关肽（CGRP）。神经肽CGRP和IAPP之间的结构相似性支持IAPP本质上是激素的前提。我们的免疫组织化学研究还表明，几种哺乳动物（包括人和猫）的正常胰岛B-细胞与针对IAPP合成肽段的抗血清产生强烈的免疫反应性。IAPP作为淀粉样蛋白沉积在2型（非胰岛素依赖型）糖尿病患者的胰岛中的事实强烈支持IAPP与这种疾病的发展之间的重要但未知的联系。
The discovery of a novel polypeptide (Islet Amyloid Polypeptide: IAPP) isolated from human and cat islet amyloid and from amyloid of a human insulinoma is reviewed. Structurally, IAPP from the human and cat resembles calcitonin gene‐related peptide (CGRP). The structural similarities between the neuropeptide CGRP and IAPP support the premise that IAPP is hormonal in nature. Our immunohistochemical studies also indicate that normal islet B‐cells of several mammalian species (including man and cat) give strong immunoreactivity with antiserum directed to a synthetic peptide segment of IAPP. The fact that IAPP is deposited as amyloid in the pancreatic islets of type 2 (noninsulin‐dependent) diabetics strongly supports an important but yet unknown link between IAPP and the development of this disease.