First serological investigation of peste-des-petits-ruminants and Rift Valley fever in Tunisia
First serological investigation of peste-des-petits-ruminants and Rift Valley fever in Tunisia
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DOI：
10.1016/j.tvjl.2010.01.007
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发表时间：
2011-03-01
影响因子：
2.2
通讯作者：
Cetre-Sossah, Catherine
中科院分区：
文献类型：
--
作者：
Ayari-Fakhfakh, Emna;Ghram, Abdeljelil;Cetre-Sossah, Catherine
这项研究于2006年9月至2007年1月期间开展，是突尼斯首次对小反刍兽疫（PPR）和裂谷热（RVF）进行横断面血清学调查。目的是评估开发一种双重重组小疫病毒-裂谷热疫苗的潜在需求，以及如何在突尼斯使用这种疫苗。该ELISA的高特异性（99.4%）和高灵敏度（94.5%）支持了小反胃病毒总血清阳性率为7.45%。通过对采样区蚊虫多样性和密度的评估，鉴定出伊蚊和库蚊4种裂谷热媒介。然而，尽管使用了高度敏感的ELISA(99-100%)，仍未发现裂谷热的血清学证据。正在进行更大规模的调查，以证实这些发现，针对这两种疾病的紧急疫苗接种规划继续有效。(C) 2010 Elsevier Ltd.版权所有。
This study, carried out between September 2006 and January 2007, is the first cross-sectional serological investigation of peste-des-petits-ruminants (PPR) and Rift Valley fever (RVF) in Tunisia. The objective was to assess the potential need to develop a dual, recombinant PPR-RVF vaccine and how such a vaccine might be utilised in Tunisia. An overall PPR seroprevalence of 7.45% was determined, a finding supported by the high specificity (99.4%) and sensitivity (94.5%) of the ELISA used. On assessment of the diversity and density of mosquitoes in the sampling area, four species of RVF-vectors of the genus Aedes and Culex were identified. However, no serological evidence of RVF was found despite the use of a highly sensitive ELISA (99-100%). Larger scale investigations are underway to confirm these findings and the continuation of the emergency vaccination program against these two diseases remains valid. (C) 2010 Elsevier Ltd. All rights reserved.