The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid
The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid
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DOI：
10.1051/rnd:2006033
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发表时间：
2006-09-01
期刊：
影响因子：
--
通讯作者：
Chardigny, Jean-Michel
中科院分区：
文献类型：
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作者：
Acar, Niyazi;Bonhomme, Brigitte;Chardigny, Jean-Michel
反式多不饱和脂肪酸是在植物油的热处理过程中由含有顺式双键的多不饱和脂肪酸形成的。饮食摄入后，它们分布在体内，并被纳入神经组织，包括视网膜。由于已知神经组织富含n-3脂肪酸，如二十二碳六烯酸（DHA），因此我们研究了视网膜和大脑吸收体内由饮食前体反式α-亚麻酸形成的DHA反式异构体的能力。用α-亚麻酸的反式异构体喂养Wistar大鼠21个月。在视网膜中观察到反式DHA的线性掺入和顺式DHA的减少，而在大脑中没有观察到重大变化。与视网膜顺式和反式DHA水平的变化平行，通过视网膜电图评估的视网膜功能显示消耗反式α-亚麻酸的动物存在缺陷。这些结果表明，导致顺式和反式脂肪酸的掺入的机制是相当不同的视网膜相比，大脑和肝脏，视网膜更容易受到饮食中的脂质贡献的变化。
Trans polyunsaturated fatty acids are formed during heat treatments of vegetable oils from polyunsaturated fatty acids containing cis double bonds. After dietary intake, they are distributed in the body and are incorporated into nervous tissues including the retina. Since nervous tissues are known to be rich in n-3 fatty acids such as docosahexaenoic acid (DHA), we studied the ability of the retina and the brain to incorporate trans isomers of DHA formed in vivo from the dietary precursor trans alpha-linolenic acid. Wistar rats were fed with trans isomers of alpha-linolenic acid for 21 months. A linear incorporation of trans DHA and a decrease in cis DHA was observed in the retina, whereas no major changes were observed in the brain. In parallel to the modifications in retinal cis and trans DHA levels, the retinal functionality evaluated by the electroretinogram showed defects in animals that consumed trans alpha-linolenic acid. These results suggest that the mechanisms leading to the incorporation of cis and trans fatty acids are quite different in the retina when compared to the brain and the liver, the retina being more susceptible to changes in the dietary lipid contribution.