Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study
Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study
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DOI：
10.1038/nnano.2008.111
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发表时间：
2008-07-01
影响因子：
38.3
通讯作者：
Donaldson, Ken
中科院分区：
文献类型：
--
作者：
Poland, Craig A.;Duffin, Rodger;Donaldson, Ken
碳纳米管（1）具有独特的特征（2），但它们的针状纤维形状已被与石棉（3）进行比较，引起了人们对碳纳米管的广泛使用可能导致间皮瘤的担忧，间皮瘤是由暴露于石棉引起的肺部衬里癌症（4）。在这里，我们表明，暴露的mesotherapy内衬的小鼠的体腔，作为替代的mesotherapy内衬的胸腔，长的多壁碳纳米管的石棉样，长度依赖性，致病行为的结果。这包括炎症和称为肉芽肿的病变的形成。这是相当重要的，因为研究和商业界继续大量投资于碳纳米管用于各种产品（5），假设它们不比石墨更危险。我们的研究结果表明，如果要避免长期伤害，在将此类产品引入市场之前需要进一步研究和非常谨慎。
Carbon nanotubes(1) have distinctive characteristics(2), but their needle-like fibre shape has been compared to asbestos(3), raising concerns that widespread use of carbon nanotubes may lead to mesothelioma, cancer of the lining of the lungs caused by exposure to asbestos(4). Here we show that exposing the mesothelial lining of the body cavity of mice, as a surrogate for the mesothelial lining of the chest cavity, to long multiwalled carbon nanotubes results in asbestos-like, length-dependent, pathogenic behaviour. This includes inflammation and the formation of lesions known as granulomas. This is of considerable importance, because research and business communities continue to invest heavily in carbon nanotubes for a wide range of products(5) under the assumption that they are no more hazardous than graphite. Our results suggest the need for further research and great caution before introducing such products into the market if long-term harm is to be avoided.