Epigenetic Regulation of Differentially Expressed Drug-Metabolizing Enzymes in Cancer
Epigenetic Regulation of Differentially Expressed Drug-Metabolizing Enzymes in Cancer
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DOI：
10.1124/dmd.120.000008
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发表时间：
2020-06
影响因子：
3.9
通讯作者：
Jiaqi Wang;Lushan Yu;Huidi Jiang;Xiaoli Zheng;S. Zeng
中科院分区：
文献类型：
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作者：
Jiaqi Wang;Lushan Yu;Huidi Jiang;Xiaoli Zheng;S. Zeng
药物代谢是药物在药物代谢酶（DME）催化下的生物转化过程，包括I相DME和II相DME。DME的异常表达发生在癌症的不同阶段。它可以通过影响致癌物质和抗癌药物的代谢过程，促进癌症的发展，并导致药物反应的个体差异。除了我们所知最多的遗传多态性，目前的证据表明，表观遗传调控也是DME表达的核心。本文综述了差异表达的DME在癌症和相关的表观遗传变化，包括DNA甲基化，组蛋白修饰，和非编码RNA。探索差异表达的DME的表观遗传学调控可以为实施个体化和合理化用药提供依据。同时，它可以促进新的生物标志物和靶点的开发，用于癌症的诊断，治疗和预后。本文综述了DME在肿瘤中的异常表达及其相关的表观遗传学调控。探索DME在癌症中的表观遗传调控机制有助于我们理解DME在癌症进展和化疗耐药性中的作用。此外，它为开发用于癌症诊断、治疗和预后的新生物标志物和靶标提供了基础。
Drug metabolism is a biotransformation process of drugs, catalyzed by drug-metabolizing enzymes (DMEs), including phase I DMEs and phase II DMEs. The aberrant expression of DMEs occurs in the different stages of cancer. It can contribute to the development of cancer and lead to individual variations in drug response by affecting the metabolic process of carcinogen and anticancer drugs. Apart from genetic polymorphisms, which we know the most about, current evidence indicates that epigenetic regulation is also central to the expression of DMEs. This review summarizes differentially expressed DMEs in cancer and related epigenetic changes, including DNA methylation, histone modification, and noncoding RNAs. Exploring the epigenetic regulation of differentially expressed DMEs can provide a basis for implementing individualized and rationalized medication. Meanwhile, it can promote the development of new biomarkers and targets for the diagnosis, treatment, and prognosis of cancer. SIGNIFICANCE STATEMENT This review summarizes the aberrant expression of DMEs in cancer and the related epigenetic regulation of differentially expressed DMEs. Exploring the epigenetic regulatory mechanism of DMEs in cancer can help us to understand the role of DMEs in cancer progression and chemoresistance. Also, it provides a basis for developing new biomarkers and targets for the diagnosis, treatment, and prognosis of cancer.