Pregelatinized starch in the controlled release formulation
Pregelatinized starch in the controlled release formulation
复制标题
控释制剂中的预胶化淀粉
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
バンデクルイス，ロジエ・ペトルス・ゲレベルン
中科院分区：
文献类型：
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作者：
ジヤン，ユージーン・マリー・ジヨゼフ;バンデクルイス，ロジエ・ペトルス・ゲレベルン
(57)翻译后摘要：本发明，剂量的亲水性控释制剂-使用预胶化淀粉，以防止倾倒。本发明还涉及一种亲水性控释制剂，更具体地说是一种亲水性控释基质制剂，并且优选地是一种由它们制备的用于每日一次口服给药的固体剂型。包含一种或多种活性成分的亲水性控释制剂、预胶化淀粉，包括一种或多种粘性亲水性聚合物和任选的药学上可接受的配制剂。合适的亲水性聚合物包括羟丙基纤维素和羟丙基甲基纤维素。
(57) Abstract: The present invention, dose of a hydrophilic controlled release formulation - the use of pregelatinized starch to prevent dumping. The present invention also relates to a hydrophilic controlled release formulation, more particularly a hydrophilic controlled release matrix formulation, and preferably a solid dosage form prepared from them for once-daily oral administration. Hydrophilic controlled release formulation, pre-gelatinized starch, comprising one or more active ingredients, include one or more viscous hydrophilic polymers and optionally pharmaceutically acceptable formulating agents. Suitable hydrophilic polymers include hydroxypropyl cellulose and hydroxypropyl methylcellulose.