BmKCT toxin inhibits glioma proliferation and tumor metastasis
BmKCT toxin inhibits glioma proliferation and tumor metastasis
复制标题
BmKCT 毒素抑制神经胶质瘤增殖和肿瘤转移。
DOI：
10.1016/j.canlet.2009.10.011
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发表时间：
2010-05-28
期刊：
影响因子：
9.7
通讯作者：
Li, Wenxin
中科院分区：
文献类型：
--
作者：
Fan, Shaozhong;Sun, Zhengbo;Li, Wenxin
恶性胶质瘤是最常见的原发性脑肿瘤，具有显著的发病率和死亡率。如何靶向肿瘤，抑制肿瘤细胞的增殖和侵袭是治疗的关键。胶质瘤表达胶质瘤特异性氯离子通道，其对包括BmKCT在内的毒素敏感。在本研究中，BmKCT对胶质瘤生长的抑制作用在体内使用胶质瘤/SD大鼠模型观察。此外，BmKCT在体内抑制胶质瘤细胞的转移。此外，用I-131标记或Cy5.5缀合的BmKCT的生物分布实验显示，BmKCT选择性地原位靶向胶质瘤。我们的数据表明，BmKCT可以作为一个潜在的治疗胶质瘤的诊断和治疗。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Malignant gliomas are the most common primary brain tumors associated with significant morbidity and mortality. How to target the tumor in situ, and inhibit tumor cell proliferation and invasion is the key for therapy. Gliomas express a glioma-specific chloride ion channel that is sensitive to toxins including BmKCT. In the current study, the inhibitory effect of BmKCT on glioma growth was observed in vivo using the glioma/SD rat model. Furthermore, BmKCT prevented the metastasis of glioma cells in vivo. Moreover, biodistribution experiments with I-131-labeled or Cy5.5-conjugated BmKCT revealed that BmKCT selectively targeted the glioma in situ. Our data suggest that BmKCT could be exploited as a potential therapeutic for glioma diagnosis and therapy. (C) 2009 Elsevier Ireland Ltd. All rights reserved.