Glial abnormalities in mood disorders.
Glial abnormalities in mood disorders.
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情绪障碍中的神经胶质异常。
DOI：
10.1097/hrp.0000000000000060
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发表时间：
2014
影响因子：
3.8
通讯作者：
Cohen,BruceM
中科院分区：
文献类型：
--
作者：
Öngür,Dost;Bechtholt,AnitaJ;CarlezonJr,WilliamA;Cohen,BruceM
多种证据表明，情绪障碍与大脑细胞组成的异常有关，特别是神经胶质细胞。胶质细胞在过去被认为是惰性的支持细胞，现在人们知道它对大脑功能很重要。情绪障碍的治疗可以促进神经胶质细胞的增殖，并且在情绪障碍的动物模型中，对细胞生长的实验性刺激具有抗抑郁作用。这些发现表明，神经胶质细胞的增殖和存活可能在情绪障碍的发病机制中很重要，并可能成为开发新治疗方法的可能靶点。在这篇文章中，我们回顾了情绪障碍中神经胶质异常的证据，我们讨论了神经胶质细胞生物学和情绪障碍尸检研究的证据。我们的目标不是进行全面的审查，而是有选择地讨论现有的证据，以支持神经胶质细胞在情绪障碍中的作用。
Multiple lines of evidence indicate that mood disorders are associated with abnormalities in the brain’s cellular composition, especially in glial cells. Considered inert support cells in the past, glial cells are now known to be important for brain function. Treatments for mood disorders enhance glial cell proliferation, and experimental stimulation of cell growth has antidepressant effects in animal models of mood disorders. These findings suggest that the proliferation and survival of glial cells may be important in the pathogenesis of mood disorders and may be possible targets for the development of new treatments. In this article we review the evidence for glial abnormalities in mood disorders, and we discuss glial cell biology and evidence from postmortem studies of mood disorders. The goal is not to carry out a comprehensive review but to selectively discuss existing evidence in support of an argument for the role of glial cells in mood disorders.