A NEW HEPARIN BINDING-PROTEIN REGULATED BY RETINOIC ACID FROM CHICK-EMBRYO
A NEW HEPARIN BINDING-PROTEIN REGULATED BY RETINOIC ACID FROM CHICK-EMBRYO
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DOI：
10.1016/0006-291x(91)91475-r
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发表时间：
1991-01-31
影响因子：
3.1
通讯作者：
VIGNY, M
中科院分区：
文献类型：
--
作者：
RAULAIS, D;LAGENTECHEVALLIER, O;VIGNY, M
一个19 KDa的肝素结合蛋白，以前从鸡胚中纯化。这种蛋白质基本上位于早期胚胎组织的基底膜内，富含碱性和半胱氨酸残基。它的N-末端片段与胚胎发育和出生后时期表达的另外两种蛋白的相应片段相似。视黄酸诱导鸡成肌细胞和成纤维细胞合成和分泌。这种新的维甲酸诱导的肝素结合蛋白（RI-HB）确实刺激PC 12细胞上的神经突生长和增殖。这些结果表明，视黄酸可以通过诱导一个新的生长和神经营养因子家族的合成来调节分化和发育的某些方面。
A 19 KDa heparin binding protein was previously purified from chicken embryos. Essentially localized within basement membranes in early embryonic tissues, this protein is very rich in basic and cystein residues. Its N-terminal fragment is similar to corresponding fragment of two other proteins expressed during embryogenesis and postnatal period. Its synthesis and secretion are induced by retinoic acid in chicken myoblasts and fibroblasts. This new retinoic acid induced heparin binding protein (RI-HB) does stimulate neurite outgrowth and proliferation on PC12 cells. These results suggest that retinoic acid could regulate some aspect of differentiation and development by inducing the synthesis of a new family of growth and neurotrophic factors.