Neural activations are related to body-shape, anxiety, and outcomes in adolescent anorexia nervosa.
Neural activations are related to body-shape, anxiety, and outcomes in adolescent anorexia nervosa.
复制标题
神经激活与青少年神经性厌食症的体型、焦虑和结果有关。
DOI：
10.1016/j.jpsychires.2016.12.005
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发表时间：
2017
影响因子：
4.8
通讯作者：
McAdams,CarrieJ
中科院分区：
文献类型：
--
作者：
Xu,Jie;Harper,JessicaA;VanEnkevort,ErinA;Latimer,Kelsey;Kelley,Urszula;McAdams,CarrieJ
神经性厌食症（AN）是一种经常在青春期开始并涉及体重减轻的疾病。两组青春期女孩（AN-A，AN后体重恢复）和（HC-A，健康对照）完成了一项涉及社会评价的功能性磁共振成像任务，允许比较自我评价，朋友评价和自我评价时的神经激活。虽然两组在全脑激活方面没有差异，但焦虑和体型问题与先验感兴趣区域的神经活动相关。内侧前额叶皮层和背侧前扣带皮层的一个集群与体型问卷相关;对体型有更多关注的受试者在自我评价时使用这一区域的次数少于对朋友的评价。内侧前额叶皮质和扣带回中的集群也与焦虑相关，因此在自我评价期间，当不同意而不是同意社交术语时，更多的焦虑与参与有关。这些数据表明，在社会评价过程中额叶脑区的利用率的差异可能有助于焦虑和体型的关注，在青少年与AN。获得了临床随访，从而可以探索疾病早期的脑功能是否与疾病轨迹有关。成功恢复的青少年使用后扣带回和楔前叶更多的朋友比自我评价的青少年，仍然生病，这表明与社会评价相关的神经差异可能提供临床预测价值。利用MPFC和楔前叶在社会和自我评价可能是一个关键的生物组成部分，实现持续的体重恢复青少年与AN。
Anorexia nervosa (AN) is an illness that frequently begins during adolescence and involves weight loss. Two groups of adolescent girls (AN-A, weight-recovered following AN) and (HC-A, healthy comparison) completed a functional magnetic resonance imaging task involving social evaluations, allowing comparison of neural activations during self-evaluations, friend-evaluations, and perspective-taking self-evaluations. Although the two groups were not different in their whole-brain activations, anxiety and body shape concerns were correlated with neural activity in a priori regions of interest. A cluster in medial prefrontal cortex and the dorsal anterior cingulate correlated with the body shape questionnaire; subjects with more body shape concerns used this area less during self than friend evaluations. A cluster in medial prefrontal cortex and the cingulate also correlated with anxiety such that more anxiety was associated with engagement when disagreeing rather than agreeing with social terms during self-evaluations. This data suggests that differences in the utilization of frontal brain regions during social evaluations may contribute to both anxiety and body shape concerns in adolescents with AN. Clinical follow-up was obtained, allowing exploration of whether brain function early in course of disease relates to illness trajectory. The adolescents successful in recovery used the posterior cingulate and precuneus more for friend than self evaluations than the adolescents that remained ill, suggesting that neural differences related to social evaluations may provide clinical predictive value. Utilization of both MPFC and the precuneus during social and self evaluations may be a key biological component for achieving sustained weight-recovery in adolescents with AN.