Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology.
Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology.
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DOI：
10.1002/dad2.12321
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发表时间：
2022
影响因子：
5.3
通讯作者：
VandeVrede, Lawren
中科院分区：
文献类型：
--
作者：
Berry, Kacey;Asken, Breton M.;Grab, Joshua D.;Chan, Brandon;Lario Lago, Argentina;Wong, Randi;Seetharaman, Srilakshmi;LaHue, Sara C.;Possin, Katherine L.;Rojas, Julio C.;Kramer, Joel H.;Boxer, Adam L.;Lai, Jennifer C.;VandeVrede, Lawren
肝肾功能对神经病理学血浆生物标志物的影响尚不清楚。在此，我们测量了肝硬化患者的几种血浆生物标志物。使用Simoa测定了135名肝硬化成人和22名健康对照者的血浆磷酸化tau蛋白（p-tau 181）、神经丝轻链（NfL）、胶质细胞酸性蛋白（GFAP）、总tau蛋白（t-tau）和泛素羧基末端水解酶L1（UCHL 1）。在肝硬化中，使用线性回归探索生物标志物和肝肾功能之间的关联。在肝硬化患者中，p-tau 181、NfL、t-tau和UCHL 1增加了2 - 4倍，而GFAP没有增加。在肝硬化中，肌酐与p-tau 181中度相关（β = 0.75，P < .01），NfL（β = 0.32，P <0.01），和t-tau（β = 0.31，P <0.01），而GFAP则无（β =-0.01，P = .88）或UCHL 1（β =-0.05，P = 0.60），而白蛋白显示弱的负相关：p-tau 181（β =-0.18，P < .01）、NfL（β =-0.22，P < .01）、GFAP（β =-0.17，P < .05）、t-tau（β =-0.20，P = .02）和UCHL1（β =-0.15，P = .09）。肝硬化患者p-tau 181、NfL和t-tau水平升高与肾损害和低白蛋白血症相关，提示肝肾功能在解释神经病理学的血浆生物标志物时可能很重要。
The impact of hepatorenal function on plasma biomarkers of neuropathology is unknown. Herein, we measured several plasma biomarkers in patients with cirrhosis. Plasma phosphorylated tau (p‐tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tau (t‐tau), and ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) were measured in 135 adults with cirrhosis and 22 healthy controls using Simoa. Within cirrhosis, associations between biomarkers and hepatorenal function were explored using linear regression. p‐tau181, NfL, t‐tau, and UCHL1 were increased 2‐ to 4‐fold in cirrhosis, whereas GFAP was not increased. Within cirrhosis, creatinine moderately correlated with p‐tau181 (β = 0.75, P < .01), NfL (β = 0.32, P < .01), and t‐tau (β = 0.31, P < .01), but not GFAP (β = –0.01, P = .88) or UCHL1 (β = –0.05, P = .60), whereas albumin showed weak, inverse correlations: p‐tau181 (β = –0.18, P < .01), NfL (β = –0.22, P < .01), GFAP (β = –0.17, P < .05), t‐tau (β = –0.20, P = .02), and UCHL1 (β = –0.15, P = .09). Elevated p‐tau181, NfL, and t‐tau in cirrhosis were associated with renal impairment and hypoalbuminemia, suggesting that hepatorenal function may be important when interpreting plasma biomarkers of neuropathology.
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影响因子：
6.8
作者：
Chatterjee P;Pedrini S;Stoops E;Goozee K;Villemagne VL;Asih PR;Verberk IMW;Dave P;Taddei K;Sohrabi HR;Zetterberg H;Blennow K;Teunissen CE;Vanderstichele HM;Martins RN
通讯作者：
Martins RN
影响因子：
5.1
作者：
Berry K;Duarte-Rojo A;Grab JD;Dunn MA;Boyarsky BJ;Verna EC;Kappus MR;Volk ML;McAdams-DeMarco M;Segev DL;Ganger DR;Ladner DP;Shui A;Tincopa MA;Rahimi RS;Lai JC;from the Multi-Center Functional Assessment in Liver Transplantation (FrAILT) Study
通讯作者：
from the Multi-Center Functional Assessment in Liver Transplantation (FrAILT) Study
影响因子：
82.9
作者：
Thijssen, Elisabeth H.;La Joie, Renaud;Boxer, Adam L.
通讯作者：
Boxer, Adam L.
淀粉样蛋白和神经退行性血浆生物标志物与合并症的关联。
DOI：
10.1002/alz.12466
发表时间：
2022-06
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Syrjanen JA;Campbell MR;Algeciras-Schimnich A;Vemuri P;Graff-Radford J;Machulda MM;Bu G;Knopman DS;Jack CR Jr;Petersen RC;Mielke MM
通讯作者：
Mielke MM
影响因子：
29
作者：
Rubenstein R;Chang B;Yue JK;Chiu A;Winkler EA;Puccio AM;Diaz-Arrastia R;Yuh EL;Mukherjee P;Valadka AB;Gordon WA;Okonkwo DO;Davies P;Agarwal S;Lin F;Sarkis G;Yadikar H;Yang Z;Manley GT;Wang KKW;the TRACK-TBI Investigators;Cooper SR;Dams-O'Connor K;Borrasso AJ;Inoue T;Maas AIR;Menon DK;Schnyer DM;Vassar MJ
通讯作者：
Vassar MJ