Bone Microarchitecture and Stiffness in Premenopausal Women with Idiopathic Osteoporosis
Bone Microarchitecture and Stiffness in Premenopausal Women with Idiopathic Osteoporosis
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DOI：
10.1210/jc.2009-0996
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发表时间：
2009-11-01
影响因子：
5.8
通讯作者：
Shane, Elizabeth
中科院分区：
文献类型：
--
作者：
Cohen, Adi;Liu, X. Sherry;Shane, Elizabeth
内容：特发性骨质疏松症（IOP）是一种不常见的疾病，在绝经前健康的妇女中会发生低面积骨密度（aBMD）和/或骨折。目的：我们的目的是描述绝经前IOP的骨量、微结构和骨小梁硬度，并确定从未骨折的低aBMD妇女是否有异常的微结构和硬度。设计、设置和患者：我们对27名正常对照和31名患有低创伤骨折（n = 21）或低BMD（Z评分）的IOP的女性进行了前瞻性队列研究
Context: Idiopathic osteoporosis (IOP) is an uncommon disorder in which low areal bone mineral density (aBMD) and/or fractures occur in otherwise healthy premenopausal women.Objectives: Our objectives were to characterize bone mass, microarchitecture, and trabecular bone stiffness in premenopausal IOP and to determine whether women with low aBMD who have never fractured have abnormal microarchitecture and stiffness.Design, Setting, and Patients: We conducted a prospective cohort study of 27 normal controls and 31 women with IOP defined by low trauma fracture (n = 21) or low BMD (Z score