Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons.
Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons.
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DOI：
10.3389/fcell.2022.1022544
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
II组代谢型谷氨酸（mGlu）受体（mGlu2/3）是一种Gαi/o偶联受体，主要位于中枢神经系统的突触前轴突末端。与嗜离子型谷氨酸受体一样，II组mGlu受体也受翻译后磷酸化的调控。药理学证据表明，几种丝氨酸/苏氨酸蛋白激酶具有调节mGlu2/3受体的能力。磷酸化残基的详细图谱显示，在异源细胞或神经元中，蛋白激酶A （PKA）在mGlu2/3受体胞内c末端末端的特定丝氨酸位点磷酸化mGlu2/3受体，这是mGlu2/3信号生理调节的基础。酪蛋白激酶促进mGlu2在特定位点的磷酸化。酪氨酸蛋白激酶也靶向II组受体诱导强效磷酸化。发现一种蛋白磷酸酶特异性结合mGlu3受体，并在pka敏感部位使该受体去磷酸化。本文综述了近年来在II族受体磷酸化及II族受体磷酸化依赖性调控方面的研究进展。我们进一步探讨了mGlu2/3磷酸化与各种神经和神经精神疾病的潜在联系，并讨论了未来旨在分析mGlu2/3磷酸化新的生化和生理特性的研究。
Group II metabotropic glutamate (mGlu) receptors (mGlu2/3) are Gαi/o-coupled receptors and are primarily located on presynaptic axonal terminals in the central nervous system. Like ionotropic glutamate receptors, group II mGlu receptors are subject to regulation by posttranslational phosphorylation. Pharmacological evidence suggests that several serine/threonine protein kinases possess the ability to regulate mGlu2/3 receptors. Detailed mapping of phosphorylation residues has revealed that protein kinase A (PKA) phosphorylates mGlu2/3 receptors at a specific serine site on their intracellular C-terminal tails in heterologous cells or neurons, which underlies physiological modulation of mGlu2/3 signaling. Casein kinases promote mGlu2 phosphorylation at a specific site. Tyrosine protein kinases also target group II receptors to induce robust phosphorylation. A protein phosphatase was found to specifically bind to mGlu3 receptors and dephosphorylate the receptor at a PKA-sensitive site. This review summarizes recent progress in research on group II receptor phosphorylation and the phosphorylation-dependent regulation of group II receptor functions. We further explore the potential linkage of mGlu2/3 phosphorylation to various neurological and neuropsychiatric disorders, and discuss future research aimed at analyzing novel biochemical and physiological properties of mGlu2/3 phosphorylation.
影响因子：
2.9
作者：
Mao LM;Guo ML;Jin DZ;Fibuch EE;Choe ES;Wang JQ
通讯作者：
Wang JQ