Transporters HP0939, HP0497, and HP0471 participate in intrinsic multidrug resistance and biofilm formation inHelicobacter pyloriby enhancing drug efflux
Transporters HP0939, HP0497, and HP0471 participate in intrinsic multidrug resistance and biofilm formation inHelicobacter pyloriby enhancing drug efflux
复制标题
转运蛋白 HP0939、HP0497 和 HP0471 通过增强药物流出参与幽门螺杆菌的内在多药耐药性和生物膜形成
DOI：
10.1111/hel.12715
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发表时间：
2020-06-16
期刊：
影响因子：
4.4
通讯作者：
Sun, Yundong
中科院分区：
文献类型：
--
作者：
Cai, Yuying;Wang, Caixia;Sun, Yundong
幽门螺杆菌的多药耐药问题日益严重。因此，有必要对幽门螺杆菌的多药耐药机制进行研究。我们以前已经确定，HP 0939，HP 0497和HP 0471转运蛋白影响药物从幽门螺杆菌的外排。由于外排泵参与细菌的多药耐药性和生物膜形成，我们推测这些转运蛋白可能参与幽门螺杆菌的多药耐药性和生物膜形成。
The multidrug resistance of Helicobacter pylori is becoming an increasingly serious issue. It is therefore necessary to study the mechanism of multidrug resistance of H pylori. We have previously identified that the HP0939, HP0497, and HP0471 transporters affect the efflux of drugs from H pylori. As efflux pumps participate in bacterial multidrug resistance and biofilm formation, we hypothesized that these transporters could be involved in the multidrug resistance and biofilm formation of H pylori.