Nitrite and nitrate: from bench to bedside.
Nitrite and nitrate: from bench to bedside.
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亚硝酸盐和硝酸盐：从实验室到床边。
DOI：
10.1016/j.niox.2012.04.165
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Lefer,DavidJ
中科院分区：
文献类型：
--
作者：
Kevil,ChristopherG;Lefer,DavidJ
This special issue represents recent proceedings and developments in the fields of nitrite and nitrate chemistry, biology and therapeutics that were discussed at the biannual international meeting entitled “Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy Conference”. This conference represents the fourth instillation of this meeting series that has served as a unique forum where investigators from diverse backgrounds have come together to better understand the chemical biology of nitrite and nitrate with an emphasis on therapeutic utility of nitrite and nitrate for various disease conditions.Over the three-day meeting, new information was shared regarding the biological importance of nitrite and nitrate mediated nitric oxide (NO) formation for numerous aspects of physiological homeostasis and disease states. Initial studies regarding nitrite biology and function elucidated biochemical mechanisms involved in nitrite reduction to NO under specific conditions such as tissue ischemia [1]. However, meeting presentations demonstrated that therapeutic benefits of nitrite might be more broadly beneficial than previously considered for several cardiovascular pathologies such as vascular intimal hyperplasia and vascular aging, and chemotherapeutic cardiotoxicity [2; 3; 4]. New findings were also discussed regarding the relationship between myoglobin and mitochondrial function with respect to hypoxia and nitrite/NO metabolism that are further discussed in this issue [5; 6]. Lastly, clinical and translational studies were discussed regarding the safety and efficacy of nitrite therapy for peripheral vascular diseases that are currently under way [7].
