The subunit structure of the eukaryotic chromosome
The subunit structure of the eukaryotic chromosome
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DOI：
10.1038/253245a0
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发表时间：
1975-01
期刊：
影响因子：
64.8
通讯作者：
J. Baldwin;P. Boseley;E. Bradbury;K. Ibel
中科院分区：
文献类型：
--
作者：
J. Baldwin;P. Boseley;E. Bradbury;K. Ibel
从染色质的中子散射研究中获得了新的结构数据。在10 - 11nm处，与浓度相关的子午峰来自于亚基结构的粒子间距。在5.5和3.7nm处的峰与在11.0和3.7nm处的峰具有不同的对比行为，这表明组蛋白和DNA在亚基中具有不同的空间排列。一个由组蛋白的极性片段组成的被DNA包围的核心与组蛋白的基本片段复合的球形模型与数据一致。
New structural data have been obtained from neutron scattering studies of chromatin. The concentration-dependent meridional peak at10–11nm comes from the interparticle spacing of a subunit structure. Peaks at5.5and3.7nm have a different contrast behaviour to those at11.0and3.7nm showing that histones and DNA have a different spatial arrangement in the subunit. A globular model in which apolar segments of histones form the core surrounded by DNA complexed with the basic segments of histones agrees with the data.