Mechanisms of tinnitus generation.
Mechanisms of tinnitus generation.
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DOI：
10.1097/01.moo.0000134443.29853.09
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发表时间：
2004-10-01
影响因子：
1.6
通讯作者：
Bauer, Carol A
中科院分区：
文献类型：
--
作者：
Bauer, Carol A
综述的目的：目前对耳鸣产生机制的认识正在继续推进。这篇综述旨在概述神经解剖学、生理学、心理物理学和脑成像领域的新知识，这些知识揭示了耳鸣发展的新机制。这些领域的进展将为耳鸣的有效治疗开辟新的途径。最新发现：高脉冲串电刺激耳蜗的应用可能是有效的恢复正常模式的自发活动从周边解释为编码的听觉脑干沉默。临床和实验室证据表明，躯体感觉系统和听觉系统之间存在显著的相互作用，这对于理解和治疗耳鸣具有重要意义。神经可塑性和新的成像技术的原则的应用，扩大了我们的理解耳鸣通过类似的方法幻肢痛。最后，一种新的受体类型最近位于听觉神经血管结构开辟了一个新的领域的炎症机制的研究，有助于耳鸣。概要：我们的理解的机制，导致幻听的看法，以及相关的衰弱的后果，这种感觉的经验，是继续改善。耳鸣似乎以复杂的方式受到躯体感觉、边缘系统和运动影响的显著影响。有效的治疗方法肯定会从这些新的研究领域中出现。
PURPOSE OF REVIEW: The current understanding of mechanisms of tinnitus generation is continuing to advance. This review is intended to outline new knowledge in the areas of neuroanatomy, physiology, psychophysics, and brain imaging that are revealing novel mechanisms of tinnitus development. Advances in these areas will open new avenues for effective treatment of tinnitus.RECENT FINDINGS: Application of high-pulse train electrical stimulation to the cochlea may be effective in restoring the normal pattern of spontaneous activity from the periphery that is interpreted by the auditory brainstem as coding for silence. Clinical and laboratory evidence for a significant interaction between the somatosensory and auditory systems has important implications for understanding and treating tinnitus. Application of principles of neuroplasticity and novel imaging techniques has expanded our understanding of tinnitus through analogous approaches to phantom limb pain. Finally, a novel receptor type recently located in auditory neurovascular structures has opened a new field of study of inflammatory mechanisms contributing to tinnitus.SUMMARY: Our understanding of the mechanisms that lead to a phantom auditory perception, and the associated debilitating consequences of this sensory experience, is continuing to improve. Tinnitus appears to be significantly affected in complex ways by somatosensory, limbic, and motor influences. Effective treatments will certainly emerge from these new areas of research.