PERIFOVEAL MICROCIRCULATION WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS
PERIFOVEAL MICROCIRCULATION WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS
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DOI：
10.1007/bf00184010
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发表时间：
1994-04-01
影响因子：
2.7
通讯作者：
REIM, M
中科院分区：
文献类型：
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作者：
AREND, O;WOLF, S;REIM, M
通过扫描激光技术（SLO-101 Rodenstock）进行荧光素血管造影以评估中心凹周围毛细血管血流速度（v）、毛细血管密度（中心凹周围毛细血管间区域：PIA）和中心凹无血管区（FAZ）。血管造影照片被数字化存储，数据通过图像分析系统（IBAS）离线量化。在本研究中，对 46 名非胰岛素依赖型糖尿病 (NIDDM) 患者进行了检查，并将他们的数据与 31 名健康志愿者的数据进行了比较。与健康受试者（v = 2.86 +/- 0.41 mm/s）相比，NIDDM 受试者的中心凹周围毛细血管流速（v = 2.33 +/- 0.36 mm/s）显着（P < 0.01）降低。与健康受试者（PIA = 3965 +/- 467 mum2；FAZ = 0.221 +/- 0.071 mm2）相比，NIDDM 患者（PIA = 10 029 +/- 3402 mm2；FAZ = 0.415 +/- 0.272 mm2）中心凹周围毛细血管间面积显着增加。这些数据表明，NIDDM 患者可能会出现中心凹周围毛细血管血流速度降低、毛细血管密度降低（PIA 扩大）和中心凹无血管区扩大的情况。这些参数的确定有助于监测糖尿病视网膜病变和糖尿病黄斑病变的进展。
Fluorescein angiograms were performed to evaluate perifoveal capillary blood velocities (v), capillary density (perifoveal intercapillary areas: PIA) and the fovea avascular zone (FAZ) by means of the scanning laser technique (SLO-101 Rodenstock). The angiograms were digitally stored and the data quantified off-line with an image analyzing system (IBAS). In the present study 46 patients with non-insulin-dependent diabetes mellitus (NIDDM) were examined and their data compared with that of 31 healthy volunteers. The perifoveal capillary flow velocity of the NIDDM subjects (v = 2.33 +/- 0.36 mm/s) was significantly (P < 0.01) decreased as compared to healthy subjects (v = 2.86 +/- 0.41 mm/s). The perifoveal intercapillary areas in the foveal avascular zone were significantly increased in patients with NIDDM (PIA = 10 029 +/- 3402 mum2; FAZ = 0.415 +/- 0.272 mm2) as compared with healthy subjects (PIA = 3965 +/- 467 mum2; FAZ = 0.221 +/- 0.071 mm2). These data suggest the possibility that a decrease in perifoveal capillary blood velocities in combination with decreased capillary density (enlarged PIA) and an enlargement of the foveal avascular zone may occur in patients with NIDDM. The determination of these parameters could help in monitoring the progress of diabetic retinopathy and diabetic maculopathy.