The diagnostic value of serum HE4 and CA-125 and ROMA index in ovarian cancer.
The diagnostic value of serum HE4 and CA-125 and ROMA index in ovarian cancer.
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DOI：
10.3892/br.2016.682
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发表时间：
2016-07
影响因子：
2.3
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Wei SU;Li H;Zhang B
卵巢癌是女性生殖系统常见的恶性肿瘤。肿瘤标志物可作为疾病诊断的工具。本研究的目的是确定血清碳水化合物抗原125（CA-125）、人附睾蛋白4（HE4）水平以及受试者工作特征曲线下面积（ROC）和卵巢恶性肿瘤风险算法（ROMA）指数对卵巢癌的诊断价值。采用电化学发光免疫法对2013年9月至2015年5月期间158例受试者（64例卵巢癌患者、64例卵巢良性肿瘤患者和30例健康人）进行血清检测。结果显示，无论卵巢良性肿瘤组和对照组血清中HE4、CA-125水平及ROMA指数均显着高于卵巢良性肿瘤组和对照组（P<0.05）。绝经前或绝经后状态。但卵巢良性肿瘤组CA-125水平显着高于健康组（P<0.05），而HE4水平两组相似。 HE4和CA-125检测的ROMA指数敏感性较高(P<0.01)。卵巢癌组中ROMA、HE4和CA-125的ROC曲线下面积分别为0.994、0.990和0.941。 HE4在绝经前卵巢癌组中的特异性和阳性预测值分别达到98.36和95%。总之，结果表明血清HE4水平和ROMA指数是诊断卵巢癌的重要指标。然而，除了HE4和CA-125检测外，ROMA指数对于提高卵巢癌的诊断效率也极具价值。
Ovarian cancer is a common malignancy of the female reproductive system. Tumor markers serve as tools in the diagnosis of the disease. The aim of the present study was to determine the diagnostic value of sera levels of carbohydrate antigen-125 (CA-125), human epididymis protein 4 (HE4) as well as the area under the curve of the receiver operating characteristic (ROC) and the risk of ovarian malignancy algorithm (ROMA) index in ovarian cancer. The sera were measured using an electrochemiluminescence immunoassay on 158 individuals (64 patients with ovarian cancer, 64 with ovarian benign tumor and 30 healthy individuals) between September 2013 and May 2015. The results showed that levels of HE4 and CA-125 in the sera of the ovarian benign tumor group as well as their ROMA index were significantly higher (P<0.05) than those of the ovarian benign tumor and control groups, regardless of pre- or postmenopausal status. However, the level of CA-125 was significantly higher (P<0.05) in the ovarian benign tumor group compared with the healthy group, while the level of HE4 was similar in the two groups. The sensitivity of the ROMA index was higher (P<0.01) with detection of HE4 and CA-125. In the ovarian cancer group, the areas under ROC curves of ROMA, HE4 and CA-125 were 0.994, 0.990 and 0.941, respectively. The specificity and positive predictive value of HE4 in the premenopausal ovarian cancer group reached 98.36 and 95%, respectively. In conclusion, the results showed that the serum level of HE4 and the ROMA index are important indicators in the diagnosis of ovarian cancer. However, in addition to HE4 and CA-125 detection, the ROMA index is extremely valuable in improving the diagnostic efficiency of ovarian cancer.