Quantitative MRI: hidden age-related changes in brain tissue.
Quantitative MRI: hidden age-related changes in brain tissue.
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DOI：
10.1097/01.rmr.0000168069.12985.15
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Ge, Yulin
中科院分区：
文献类型：
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作者：
Inglese, Matilde;Ge, Yulin
MRI 的出现在理解与年龄相关的大脑变化方面取得了显着进展，提供了一种非侵入性工具，可以在多个时间点对正常衰老的个体进行体内研究。然而，传统的 MRI 技术无法检测和量化脑组织尸检中记录的与年龄相关的微观结构变化。更复杂的定量 MR 技术，如磁化转移成像、扩散张量成像和质子 MR 光谱，已被证明对生命周期中灰质和白质中发生的微观结构和代谢变化敏感。这篇综述重点介绍了其中一些创新的定量 MR 技术，这些技术与研究与年龄相关的隐匿性脑组织变化特别相关。正常衰老大脑中发生的分子和细胞变化的体内模式的表征对于理解正常认知衰退的病理生理学和解释观察到的神经退行性疾病的变化至关重要。
The advent of MRI has made a remarkable progress in the understanding of age-related brain changes providing a noninvasive tool to study in vivo the normally aging individuals at multiple time points. However, conventional MRI techniques are unable to detect and quantify age-related microstructural changes that have been documented at the post-mortem examination of brain tissues. More sophisticated, quantitative MR techniques such as magnetization transfer imaging, diffusion tensor imaging, and proton MR spectroscopy have been shown to be sensitive to microstructural and metabolic changes that occur in gray and white matter over the course of life span. This review highlights some of these innovative, quantitative MR techniques that are particularly relevant for the study of occult age-related brain tissue changes. Characterization of the in vivo patterns of molecular and cellular changes that occur in the normal aging brain is of crucial importance to understand the pathophysiology of normal cognitive decline and to interpret observed changes in neurodegenerative diseases.