The cytocaud: A hair cell pathology in the waltzing guinea pig
The cytocaud: A hair cell pathology in the waltzing guinea pig
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DOI：
10.1159/000064447
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发表时间：
2002-09-01
影响因子：
1.6
通讯作者：
Raphael, Y
中科院分区：
文献类型：
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作者：
Kanzaki, S;Beyer, LA;Raphael, Y
跳华尔兹的豚鼠表现出严重的内耳功能障碍，包括听觉和前庭表现。本研究的目的是表征前庭毛细胞的病理性尾状延伸，细胞尾。我们的数据表明，几乎所有的I型毛细胞在华尔兹豚鼠有cytocauds，出现作为膜结合的尾巴，包含线粒体和细胞质，进行在一个基础的方向向基底膜。这些延伸要么附着在基底膜上，要么穿透基底膜，并进一步进入细胞外基质。由厚而长（30 μ m）的富含肌动蛋白的结构制成的核支持细长的长突起。肌动蛋白核心具有周期性地沿细胞尾沿着排列的交联。我们的数据表明，细胞尾前庭毛细胞的华尔兹豚鼠是高度组织化的结构与未能脱离基底膜。版权所有（C）2002 S. Karger AG，巴塞尔。
The waltzing guinea pig displays severe inner ear dysfunction that involves both an auditory and a vestibular manifestation. The aim of this study was to characterize a pathological tail-like extension of the vestibular hair cells, the cytocaud. Our data suggest that nearly all type I hair cells in the waltzing guinea pig have cytocauds, which appear as membrane-bound tails containing mitochondria and cytoplasm that proceed in a basal direction toward the basement membrane. The extensions either attach to the basement membrane or penetrate it, and further proceed into the extracellular matrix. A core made of a thick and long (30 mum) actin-rich structure supports the slender long process. The actin core has crosslinks that are periodically placed along the length of the cytocaud. Our data suggest that the cytocauds in vestibular hair cells of the waltzing guinea pig are highly organized structures associated with a failure to detach from the basement membrane. Copyright (C) 2002 S. Karger AG, Basel.