Randomized Controlled Trial on Hemifield Eye Patching and Optokinetic Stimulation in Acute Spatial Neglect
Randomized Controlled Trial on Hemifield Eye Patching and Optokinetic Stimulation in Acute Spatial Neglect
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DOI：
10.1161/strokeaha.114.006059
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发表时间：
2014-08-01
期刊：
影响因子：
8.3
通讯作者：
Helmchen, Christoph
中科院分区：
文献类型：
--
作者：
Machner, Bjoern;Koenemund, Inga;Helmchen, Christoph
背景和目的：右半球卒中患者经常出现空间忽视，即严重缺乏对侧半球空间的意识。虽然忽视计数最强的预测中风后功能不良的结果，没有既定的治疗，特别是不为急性stage. Methods，在一项随机对照试验中，我们比较了联合治疗的hemifield眼睛修补和重复视动刺激急性中风患者忽视的自发过程。结果的措施是一个神经心理测试电池忽视以及规模的功能独立性和临床损害。在基线（第1天）、治疗后（第8天）和1个月随访（第30天）时评估结果。结果-最终分析包括21例急性右半球卒中伴忽视的患者（23例入组，2例失访）分配至治疗组（1周半视野眼睛修补和视动刺激的每日疗程，n=11）或对照组（无忽略特异性治疗，n=10）。在基线时，两组在神经心理学测试表现、临床损伤或功能障碍方面没有差异。在治疗后阶段，两组在所有这些指标上都有所改善，并且在随访时结果稳定或进一步改善。然而，在这种变化之间的治疗和control group. Conclusions，早期干预相结合的半视野眼睛修补和视动刺激急性中风患者空间忽视的自发缓解过程中没有添加剂的效果。
Background and Purpose-Right hemisphere stroke patients frequently experience spatial neglect, a severe lack of awareness for contralesional hemispace. Although neglect counts among the strongest predictors for poor functional outcome after stroke, there is no established therapy, particularly not for the acute stage.Methods-In a randomized controlled trial, we compared the combined treatment of hemifield eye patching and repetitive optokinetic stimulation in acute stroke patients with neglect to the spontaneous course. Outcome measures were a neuropsychological test battery for neglect as well as scales of functional independence and clinical impairment. Outcomes were assessed at baseline (day 1), post treatment (day 8), and at 1-month follow-up (day 30).Results-Final analysis included 21 acute right hemisphere stroke patients with neglect (23 enrolled, 2 lost to follow-up) allocated either to the treatment (1 week hemifield eye patching and daily sessions of optokinetic stimulation, n=11) or the control group (no neglect-specific treatment, n=10). At baseline, both groups did not differ in neuropsychological test performance, clinical impairment, or functional disability. At the post treatment session, both groups had improved in all these measures, and results were stable or further improved at follow-up. However, there was no significant difference in this change between the treatment and the control group.Conclusions-An early intervention of combined hemifield eye patching and optokinetic stimulation in acute stroke patients with spatial neglect has no additive effect to the spontaneous remitting course of the disorder.