Drowning in people with epilepsy - How great is the risk?
Drowning in people with epilepsy - How great is the risk?
复制标题
DOI：
10.1212/01.wnl.0000323813.36193.4d
复制
发表时间：
2008-08-19
期刊：
影响因子：
9.9
通讯作者：
Sander, J. W.
中科院分区：
文献类型：
--
作者：
Bell, G. S.;Gaitatzis, A.;Sander, J. W.
背景：众所周知，癫痫患者溺水死亡的风险增加，但关于这种风险的大小，可用的数据很少。我们的目标是使用Meta分析来量化风险。方法：通过文献搜索确定了51个癫痫患者队列，在这些队列中，可以估计癫痫患者中溺水死亡的人数和处于危险中的人的年数。人口数据来自世卫组织统计信息服务处或英国国家统计局(如有)。计算了每个队列、队列组和总人口的标准化死亡率(SMR)，并计算了95%的CI。结果：共观察到88例溺水死亡病例，与预期的4.70例相比，SMR为18.7(95%可信区间为15.0~23.1)。与基于社区的事件研究(SMR 5.4)相比，流行癫痫(SMR 18.0)、癫痫和学习障碍患者(SMR 25.7)、住院患者(SMR 96.9)和接受颞叶切除患者(SMR 41.1)的SMR显著升高。英格兰和威尔士癫痫患者的SMR为15.3。结论：癫痫患者溺水的风险是普通人群的15-19倍。重要的是，应将这些风险告知癫痫患者及其照顾者，以防止死亡。
Background: People with epilepsy are known to be at increased risk of death by drowning but there are few data available regarding the size of the risk. We aimed to quantify the risk using meta-analysis.Methods: A literature search identified 51 cohorts of people with epilepsy in whom the number of deaths by drowning in people with epilepsy and the number of person-years at risk could be estimated. Population data were taken from the WHO Statistical Information Service or from the UK Office for National Statistics where available. Standardized mortality ratios (SMRs) with 95% CIs were calculated for each cohort, for groups of cohorts, and for the total population. Additionally, an SMR for drowning in people with epilepsy in England and Wales (1999-2000) was calculated using National Registries.Results: Eighty-eight drowning deaths were observed compared with 4.70 expected, giving an SMR of 18.7 (95% CI 15.0 to 23.1). Compared with community-based incident studies (SMR 5.4), the SMR was significantly raised in prevalent epilepsy (SMR 18.0), in people with epilepsy and learning disability (SMR 25.7), in those in institutional care (SMR 96.9), and in those who had a temporal lobe excision (SMR 41.1). The SMR for people with epilepsy in England and Wales was 15.3.Conclusion: The risk of drowning in people with epilepsy is raised 15- to 19-fold compared with people in the general population. It is important that people with epilepsy and their carers be informed of these risks so that deaths can be prevented.