Oestrogen receptor expression in the normal and pre‐cancerous breast
Oestrogen receptor expression in the normal and pre‐cancerous breast
复制标题
正常和癌前乳腺中雌激素受体的表达
作者：
B. Shoker;C. Jarvis;D. Sibson;C. Walker;J. Sloane
由于雌激素与大多数乳腺癌的流行病学危险因素有关，雌激素受体阳性(ER+)细胞的数量和分布可能与疾病的发展有关。因此，在正常乳腺和从非典型增生到原位癌的原位增殖谱中研究了ER+细胞，这些细胞与发生乳腺癌的不同风险水平有关。在正常绝经前乳腺中，ER+细胞占少数，呈单一分布，周围为雌激素受体阴性(ER-−)细胞。ER+细胞随着年龄的增长而显著增加，在绝经后达到平台期，这种增加与阳性细胞在不同大小的斑块中变得相邻的趋势有关。一小部分表现为更年期变化的小叶含有90%以上的ER+细胞。这一特征的意义尚不清楚，但没有发现任何证据表明它是癌前病变。在普通型增生(非典型增生，HUT)中ER+细胞的百分率略有增加，且与年龄的关系保持不变。染色模式多样，有的病灶内ER+细胞被ER−细胞包围，有的阳性细胞群相连，有时占病变细胞总数的90%以上。而不典型导管增生(ADH)、小叶原位瘤(LIN)和导管原位癌(DCIS)均以邻接细胞阳性表达为主。此外，在这些病变中，ER+细胞数量与年龄之间的关系丢失，表明ER表达的独立性或表达该受体的细胞的增殖。推测ADH期受体表达或ER+细胞数量的异常可能是Cyclins和其他细胞周期控制蛋白异常表达的先兆，这些蛋白已被证明首先出现在DCIS中。版权所有©1999 John Wiley&Sons，Ltd.
As oestrogen is associated with most of the epidemiological risk factors for breast cancer, the number and distribution of oestrogen receptor positive (ER+) cells could have a bearing on the development of the disease. ER+ cells were thus studied in the normal breast and in the spectrum of in situ proliferations which range from non‐atypical hyperplasia to in situ carcinoma and are associated with different levels of risk for developing breast cancer. In the normal pre‐menopausal breast, ER+ cells comprised the minority and were distributed singly, being surrounded by oestrogen receptor negative (ER−) cells. ER+ cells showed a statistically significant increase with age, reaching a plateau after the menopause, and the increase was associated with a tendency for positive cells to become contiguous in patches of variable size. A small proportion of lobules showing involutional change comprised over 90 per cent ER+ cells. The significance of this feature is not clear but no evidence was found that it was pre‐cancerous. The percentage of ER+ cells was slightly increased in hyperplasia of usual type (non‐atypical hyperplasia, HUT) and the relationship to age was maintained. The staining pattern was variable; in some lesions ER+ cells were surrounded by ER− cells whereas in others there were contiguous groups of positive cells sometimes accounting for more than 90 per cent of cells in the lesion. In contrast, all cases of atypical ductal hyperplasia (ADH), lobular in situ neoplasia (LIN) and ductal carcinoma in situ (DCIS) exhibited positivity of contiguous cells accounting for the majority in the lesions. Furthermore, the relationship between ER+ cell numbers and age was lost in these lesions, indicating autonomy of ER expression or of proliferation of cells expressing the receptor. It is hypothesized that this dysregulation of receptor expression or of ER+ cell numbers at the ADH stage may be the precursor of abnormal expression of cyclins and other cell cycle control proteins which have been shown first to appear in DCIS. Copyright © 1999 John Wiley & Sons, Ltd.
影响因子：
11.2
作者：
R. Eckert;B. Katzenellenbogen
通讯作者：
R. Eckert;B. Katzenellenbogen