Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
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DOI：
10.1016/s0006-8993(96)00273-9
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发表时间：
1996-07-08
期刊：
影响因子：
2.9
通讯作者：
Cotman, CW
中科院分区：
文献类型：
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作者：
Neeper, SA;GomezPinilla, F;Cotman, CW
脑源性神经营养因子（BDNF）和神经生长因子（NGF）支持许多类型神经元的活力和功能，并且可能是CNS中活动依赖性变化的介质。我们研究了BDNF和NGF的mRNA水平在几个脑区的成年雄性大鼠后0，2，4，或7夜与随意访问运行的车轮。BDNF mRNA在几个脑区显著增加，最明显的是在海马和尾侧1/3的大脑皮层后2，4，和7夜的运动。BDNF mRNA的显著升高定位于海马的阿蒙角1区（CA 1）和4区（CA 4），以及尾侧新皮质和压后皮质的II-III层。海马和尾侧1/3皮质中的NGF mRNA也显著升高，主要影响海马的齿状回颗粒层（DG）和CA 4以及尾侧新皮质的II-III层。
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) support the viability and function of many types of neurons, and are likely mediators of activity-dependent changes in the CNS. We examined BDNF and NGF mRNA levels in several brain areas of adult male rats following 0, 2, 4, or 7 nights with ad libitum access to running wheels. BDNF mRNA was significantly increased in several brain areas, most notably in the hippocampus and caudal 1/3 of cerebral cortex following 2, 4, and 7 nights with exercise. Significant elevations in BDNF mRNA were localized in Ammon's horn areas 1 (CA1) and 4 (CA4) of the hippocampus, and layers II-III of the caudal neocortex and retrosplenial cortex. NGF mRNA was also significantly elevated in the hippocampus and caudal 1/3 of the cortex, affecting primarily the dentate gyrus granular layer (DG) and CA4 of the hippocampus and layers II-III in caudal neocortex.