Longitudinal evaluation of ventricular volume changes associated with mild traumatic brain injury in military service members.
Longitudinal evaluation of ventricular volume changes associated with mild traumatic brain injury in military service members.
复制标题
与军人轻度创伤性脑损伤相关的心室容积变化的纵向评估。
DOI：
10.1080/02699052.2018.1494854
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发表时间：
2018
期刊：
影响因子：
1.9
通讯作者：
ChronicEffectsofNeurotraumaConsortium
中科院分区：
文献类型：
--
作者：
Davenport,NicholasD;Gullickson,JamesT;Grey,ScottF;Hirsch,Shawn;Sponheim,ScottR;ChronicEffectsofNeurotraumaConsortium
主要目标：研究有和没有轻度创伤性脑损伤（mTBI）病史的退伍军人之间脑室-脑比率（VBR）纵向轨迹的差异，VBR是脑萎缩的一般指标。结构磁共振成像（MRI）用于计算70名有mTBI病史的退伍军人和34名无mTBI病史的退伍军人在战斗后约3年和8年的两个时间点的VBR主要结果和结果：两组都证明了VBR和年龄之间的二次关系，这与正常的发育轨迹一致。有mTBI病史的退伍军人有较大的总脑容量，但没有观察到mTBI和年龄之间的相互作用的脑容量，脑室容量，或VBR.Conclusions：在我们的纵向样本部署退伍军人，mTBI是不相关的总脑萎缩所反映的异常高VBR或异常增加VBR随时间的推移。
Primary objective: To investigate differences in longitudinal trajectories of ventricle-brain ratio (VBR), a general measure of brain atrophy, between Veterans with and without history of mild traumatic brain injury (mTBI).Research design: Structural magnetic resonance imaging (MRI) was used to calculate VBR in 70 Veterans with a history of mTBI and 34 Veterans without such history at two time points approximately 3 and 8 years after a combat deployment.Main outcomes and results: Both groups demonstrated a quadratic relationship between VBR and age that is consistent with normal developmental trajectories. Veterans with history of mTBI had larger total brain volume, but no interaction between mTBI and age was observed for brain volume, ventricular volume, or VBR.Conclusions: In our longitudinal sample of deployed Veterans, mTBI was not associated with gross brain atrophy as reflected by abnormally high VBR or abnormal increases in VBR over time.