Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
复制标题
仿骨可注射明胶/羟基磷灰石水凝胶
DOI：
10.15255/cabeq.2019.1663
复制
发表时间：
2019
影响因子：
1.5
通讯作者：
G. G. Ferrer
中科院分区：
文献类型：
--
作者：
Anamarija Rogina;Nikolina Šandrk;Laura Teruel;M. Antunović;M. Ivanković;G. G. Ferrer
生物活性合成水凝胶已经成为有前途的材料，因为它们
可以提供分子定制的生物功能和可调节的机械性能。到
模拟天然骨的矿物学和有机成分，羟基磷灰石，
明胶的酪胺缀合物在该研究中组合。明胶-酪胺中原位合成羟基磷灰石的量对形貌的影响
并对可注射水凝胶的物理性能进行了研究。矿物学鉴定证实了原位形成的羟基磷灰石的成功沉淀。发现在5%的羟基磷灰石下，羟基磷灰石晶体附聚物在改性明胶内更好地分布，这可能是相对于纯明胶水凝胶增加储能模量的原因。制备的复合水凝胶无毒，
Hek 293细胞的增殖。
Bioactive synthetic hydrogels have emerged as promising materials because they
can provide molecularly tailored biofunctions and adjustable mechanical properties. To
mimic the mineralogical and organic components of the natural bone, hydroxyapatite and
a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology
and physical properties of injectable hydrogels was investigated. Mineralogical identification confirmed successful precipitation of in situ formed hydroxyapatite. Better distribution of hydroxyapatite crystal agglomerates within modified gelatine was found at 5 % of hydroxyapatite, which could be responsible for increased storage modulus with respect to pure gelatine hydrogel. Prepared composite hydrogels are non-toxic and support
the proliferation of Hek293 cells.