Highly Catalytic Nanodots with Renal Clearance for Radiation Protection
Highly Catalytic Nanodots with Renal Clearance for Radiation Protection
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具有肾清除率的高催化纳米点，用于辐射防护
DOI：
10.1021/acsnano.6b00321
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发表时间：
2016
期刊：
影响因子：
17.1
通讯作者：
Meixian Li
中科院分区：
文献类型：
--
作者：
Xiao-Dong Zhang;Jinxuan Zhang;Junying Wang;Jiang Yang;Jie Chen;Xiu Shen;Jiao Deng;Dehui Deng;Wei Long;Yuan-Ming Sun;Changlong Liu;Meixian Li
电离辐射（伽马射线和X射线）广泛应用于工业和医学领域，但由于DNA损伤和自由基的入侵，它也会对健康造成重大危害，诱发癌症、身体畸形，甚至死亡。因此，设计具有有效肾脏清除率和低毒性的协同整合的高效辐射防护剂是一个迫切的未满足的需求。在这项研究中，我们设计了超小（亚5纳米）高催化活性和半胱氨酸保护的MoS2点作为辐射防护剂，并研究了它们在电离辐射防护中的应用。体内临床前研究表明，当暴露于高能电离辐射时，经 MoS2 治疗的小鼠的存活率可明显增加至 79%。此外，MoS2点可以有助于清除体内积累的自由基，修复DNA损伤，并恢复所有重要的化学和生化指标，这表明它们作为自由基清除剂的独特作用。由于其超小的流体动力学尺寸，MoS2 点显示出快速有效的尿排泄，24 小时后超过 80% 的注射剂量从体内排出，并且长达 30 天没有引起任何明显的毒性反应。
Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 nm) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days.