Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes
Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes
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DOI：
10.1016/j.neures.2011.05.013
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发表时间：
2011-09-01
影响因子：
2.9
通讯作者：
Kitazawa, Shigeru
中科院分区：
文献类型：
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作者：
Yoshimi, Kenji;Naya, Yuuki;Kitazawa, Shigeru
奖励诱导的多巴胺能神经元的爆发放电主要在灵长类动物中脑进行研究。伏安法可以高速检测投射区域的多巴胺释放。虽然伏安法已经揭示了纹状体中多巴胺释放的突触前调节，但迄今为止，在清醒的大脑中，奖励诱导的释放只在啮齿动物中被记录下来。为了录制这样的录音，可以在猴子的大脑中使用传统的碳纤维，但这些纤维的使用受到其物理脆弱性的限制。在这项研究中，恒电位安培法应用于新型金刚石微电极，用于多巴胺的高速检测。在灵长类动物的大脑中，在巴甫洛夫线索奖励试验中，在日本猴子的尾状核中发现了对奖励线索的强烈反应。总的来说，这种方法可以测量大脑特定目标区域的单胺释放，由此得出的发现将扩展通过单位记录获得的奖励反应的知识。(C) 2011爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Reward-induced burst firing of dopaminergic neurons has mainly been studied in the primate midbrain. Voltammetry allows high-speed detection of dopamine release in the projection area. Although voltammetry has revealed presynaptic modulation of dopamine release in the striatum, to date, reward-induced release in awakened brains has been recorded only in rodents. To make such recordings, it is possible to use conventional carbon fibres in monkey brains but the use of these fibres is limited by their physical fragility. In this study, constant-potential amperometry was applied to novel diamond microelectrodes for high-speed detection of dopamine. In primate brains during Pavlovian cue-reward trials, a sharp response to a reward cue was detected in the caudate of Japanese monkeys. Overall, this method allows measurements of monoamine release in specific target areas of large brains, the findings from which will expand the knowledge of reward responses obtained by unit recordings. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.