Engagement of the scavenger receptor is not responsible for β-amyloid stimulation of monocytes to a neurocytopathic state
Engagement of the scavenger receptor is not responsible for β-amyloid stimulation of monocytes to a neurocytopathic state
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DOI：
10.1006/exnr.1999.7265
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发表时间：
2000-01-01
影响因子：
5.3
通讯作者：
Pachter, JS
中科院分区：
文献类型：
--
作者：
Antic, A;Dzenko, KA;Pachter, JS
通过实验确定清道夫受体（SRs）是否在β淀粉样蛋白（AP）刺激外周血单核细胞（PBM）神经毒性中起作用。结果表明，AP不会阻断SR配体二乙酰化低密度脂蛋白与PBM的结合，而另一种SR配体岩藻苷也不会抑制AP-PBM的结合。此外，这三种SR配体都不会单独刺激PBM的神经毒性，也不会拮抗AP激活PBM到神经细胞病变状态的能力。这些发现表明，Ap的作用并不依赖于SR配体结合域的参与，并对SR在Ap神经毒性中的作用提出了质疑。(C) 2000年学术出版社。
Experiments were performed to determine if scavenger receptors (SRs) play a role in amyloid beta (AP) stimulation of peripheral blood monocyte (PBM) neurotoxicity. Results indicate that AP does not block binding of the SR ligand DiI-acetylated low density lipoprotein to PBM, nor does another SR ligand, fucoidin, inhibit AP-PBM binding. Moreover, neither of three SR ligands alone stimulates neurotoxicity in PBM, nor antagonizes the ability of AP to activate PBM to a neurocytopathic state. Such findings suggest that Ap's action is not dependent upon engagement of the SR ligand binding domain and raise doubts about the role of SR in AP neurotoxicity. (C) 2000 Academic Press.