Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria
Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria
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DOI：
10.1016/j.cell.2017.11.001
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发表时间：
2017-11-30
期刊：
影响因子：
64.5
通讯作者：
Massberg, Steffen
中科院分区：
文献类型：
--
作者：
Gaertner, Florian;Ahmad, Zerkah;Massberg, Steffen
血小板对于止血和血栓形成至关重要，并且在免疫应答期间发挥多种作用。尽管在哺乳动物生物学中有这些多功能的任务，但它们在细胞水平上的技能被认为是有限的，主要包括滚动，粘附和聚集体形成。在这里，我们确定了一个不受重视的资产血小板，并表明粘附血小板使用粘附受体机械探针在其局部微环境中的粘合剂基板。当肌动球蛋白依赖性牵引力克服基质阻力时，血小板迁移并与任何结合的颗粒材料一起堆积在粘合剂基质上。它们利用这种能力充当细胞清道夫，扫描血管表面寻找潜在的入侵者并收集沉积的细菌。通过移动血小板收集微生物增强了专职吞噬细胞的活性，加重了脓毒症中的炎性组织损伤。这赋予血小板在先天免疫应答中的核心作用，并将其鉴定为在严重全身性感染的临床情况下抑制炎性组织损伤的潜在靶点。
Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune responses. Despite these versatile tasks in mammalian biology, their skills on a cellular level are deemed limited, mainly consisting in rolling, adhesion, and aggregate formation. Here, we identify an unappreciated asset of platelets and show that adherent platelets use adhesion receptors to mechanically probe the adhesive substrate in their local microenvironment. When actomyosin-dependent traction forces overcome substrate resistance, platelets migrate and pile up the adhesive substrate together with any bound particulate material. They use this ability to act as cellular scavengers, scanning the vascular surface for potential invaders and collecting deposited bacteria. Microbe collection by migrating platelets boosts the activity of professional phagocytes, exacerbating inflammatory tissue injury in sepsis. This assigns platelets a central role in innate immune responses and identifies them as potential targets to dampen inflammatory tissue damage in clinical scenarios of severe systemic infection.