The glands have it.
The glands have it.
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腺体有它。
DOI：
10.1095/biolreprod.113.108944
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发表时间：
2013
影响因子：
3.6
通讯作者：
Sutherland,AnnE
中科院分区：
文献类型：
--
作者：
Sutherland,AnnE
For all mammals, the initial stages of development occur within the uterus, which is specialized in many ways to nourish and protect the embryo and fetus. At the heart of uterine function is the glandular epithelium (GE); it not only provides a nutrient-rich histotroph to support embryonic development until the placenta is functional [1], but it also regulates the complex coordination of activities between the embryo and uterus, thus resulting in successful implantation and placentation [2]. Implantation is initiated in the progesterone-sensitized uterus by a nidatory estradiol-17β (E 2) surge that triggers changes in the uterus, making it receptive to the embryo, and changes in the embryo making it capable of attaching and implanting [3]. In particular, substances secreted by the uterine GE, such as leukemia inhibitory factor (LIF)[4] and calcitonin [5], orchestrate changes in the luminal epithelium (LE) that permit attachment and subsequent implantation of the embryo, as well as decidualization of the underlying stromal cells (Fig. 1). LIF appears to be a primary effector of the E 2 signal, leading to activation of Stat3, changes in the expression of several genes—for example, heparin-binding EGF (HB-EGF), cochlin (Coch), insulin-like growth factor binding protein-3 (IGFBP-3), and immune response gene 1 (IRG1)(Fig. 1)—and changes in cell morphology in the LE [6, 7]. Induction of the decidual response requires not only LIF, but also a blastocyst-derived signal [7, 8], although the blastocyst signal can be replaced by a nonspecific stimulation of the LE by oil injection or mechanical scratching [9].
