Kidney Injury and Repair Biomarkers in Marathon Runners.
Kidney Injury and Repair Biomarkers in Marathon Runners.
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DOI：
10.1053/j.ajkd.2017.01.045
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Parikh CR
中科院分区：
文献类型：
--
作者：
Mansour SG;Verma G;Pata RW;Martin TG;Perazella MA;Parikh CR
随着马拉松参与的增加，对剧烈运动和肾功能的研究越来越受到关注。前瞻性观察研究参加2015年哈特福德马拉松的跑步者完成马拉松急性肾损伤（AKI）的定义，AKI网络（AKIN）标准。1期AKI定义为第0天48小时内血清肌酐升高1.5- 2倍或0.3 mg/dL， 2期定义为肌酐升高2- 3倍。显微镜评分由颗粒型和肾小管上皮细胞的数量确定。在马拉松前24小时（第0天）、马拉松后立即（第1天）和马拉松后24小时（第2天）采集样本。测定血清肌酐、肌酸激酶和尿白蛋白，并进行尿显微镜分析。检测6种损伤性尿液生物标志物（IL-6、IL-8、IL-18、肾损伤分子1、中性粒细胞明胶酶相关脂钙蛋白和肿瘤坏死因子α）和2种修复性尿液生物标志物（YKL-40和单核细胞化学引诱蛋白1）。其中包括22名马拉松运动员。平均年龄44岁，男性占41%。82%的跑步者肌酐升高，相当于akin定义的AKI 1期和2期。73%显微镜诊断为肾小管损伤。血清肌酐、尿白蛋白、损伤和修复生物标志物在第1天达到峰值，与第0天和第2天相比显著升高。从第0天到第2天，血清肌酸激酶水平继续显著升高。样本量小，所有时间点的临床数据有限。马拉松运动员发生AKI和尿沉积物诊断肾小管损伤。损伤和修复生物标志物的增加表明马拉松后肾小管发生结构性损伤。我们的研究结果应该在更大的队列和更长的肾功能随访中得到验证。
Investigation into strenuous activity and kidney function has gained interest given increasing marathon participation. Prospective observational study Runners participating in the 2015 Hartford Marathon Completing a marathon Acute kidney injury (AKI) as defined by AKI Network (AKIN) criteria. Stage 1 AKI was defined as 1.5- to 2-fold or 0.3 mg/dL increase in serum creatinine within 48 hours of day 0 and stage 2 was defined as a > 2- to 3-fold increase in creatinine. Microscopy score was defined by the number of granular casts and renal tubular epithelial cells. Samples were collected 24 hours pre-marathon (Day 0), immediately post- marathon (Day 1) and 24 hours post-marathon (Day 2). Measurements of serum creatinine, creatine kinase, and urine albumin were completed as well as urine microscopy analysis. Six injury urine biomarkers (IL-6, IL-8, IL-18, kidney injury molecule 1, neutrophil gelatinase-associated lipocalin, and tumor necrosis factor α) and two repair urine biomarkers (YKL-40 and monocyte chemoattractant protein 1) were measured. 22 marathon runners were included. Mean age was 44 years and 41% were male. 82% of runners developed a rise in creatinine equivalent to AKIN-defined AKI stages 1 and 2. 73% had microscopy diagnoses of tubular injury. Serum creatinine, urine albumin, and injury and repair biomarkers peaked on Day 1 and were significantly elevated compared to Day 0 and Day 2. Serum creatine kinase levels continued to significantly rise from Day 0 to Day 2. Small sample size and limited clinical data available at all time points. Marathon runners developed AKI and urine sediments diagnostic of tubular injury. Rise in injury and repair biomarkers suggests structural damage to renal tubules occurring after marathon. The results of our study should be validated in larger cohorts with longer follow-up of kidney function.
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影响因子：
3.3
作者：
ADAMS, WC;FOX, RH;MACDONALD, IC
通讯作者：
MACDONALD, IC
影响因子：
3.1
作者：
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