Immunological contributions to adipose tissue homeostasis.
Immunological contributions to adipose tissue homeostasis.
复制标题
免疫学对脂肪组织稳态的贡献。
DOI：
10.1016/j.smim.2015.10.005
复制
发表时间：
2015-09
影响因子：
7.8
通讯作者：
Mathis D
中科院分区：
文献类型：
--
作者：
DiSpirito JR;Mathis D
Adipose tissue is composed of many functionally and developmentally distinct cell types, the metabolic core of which is the adipocyte. The classification of “adipocyte” encompasses three primary types – white, brown, and beige – with distinct origins, anatomic distributions, and homeostatic functions. The ability of adipocytes to store and release lipids, respond to insulin, and perform their endocrine functions (via secretion of adipokines) is heavily influenced by the immune system. Various cell populations of the innate and adaptive arms of the immune system can resist or exacerbate the development of the chronic, low-grade inflammation associated with obesity and metabolic dysfunction. Here, we discuss these interactions, with a focus on their consequences for adipocyte and adipose tissue function in the setting of chronic overnutrition. In addition, we will review the effects of diet composition on adipose tissue inflammation and recent evidence suggesting that diet-driven disruption of the gut microbiota can trigger pathologic inflammation of adipose tissue.
