Comparative In Vitro Antimicrobial Activities of Torezolid (TR-700), the Active Moiety of a New Oxazolidinone, Torezolid Phosphate (TR-701), Determination of Tentative Disk Diffusion Interpretive Criteria, and Quality Control Ranges
Comparative In Vitro Antimicrobial Activities of Torezolid (TR-700), the Active Moiety of a New Oxazolidinone, Torezolid Phosphate (TR-701), Determination of Tentative Disk Diffusion Interpretive Criteria, and Quality Control Ranges
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DOI：
10.1128/aac.01569-09
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发表时间：
2010-05-01
影响因子：
4.9
通讯作者：
Traczewski, Maria M.
中科院分区：
文献类型：
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作者：
Brown, Steven D.;Traczewski, Maria M.
本研究评估了torezolid （TR-700）的活性谱，torezolid phosphate （TR-701）的活性部分，并提出了暂定的MIC和盘扩散断点以及质量控制范围。采用临床和实验室标准协会（CLSI）肉汤微量稀释mic、最低杀菌浓度（MBCs）、琼脂稀释和纸片扩散试验方法，测定了代表23个不同物种或表型组的1096株细菌对托瑞唑胺、利奈唑胺、头孢噻肟和左氧氟沙星的体外敏感性。Torezolid对大多数革兰氏阳性菌株，包括甲氧西林敏感和耐药金黄色葡萄球菌(MIC(50) = 0.25 μ g/ml， MIC(90) = 0.25 μ g/ml。
This study assessed the spectrum of activity of torezolid (TR-700), the active moiety of torezolid phosphate (TR-701), and proposes tentative MIC and disk diffusion breakpoints as well as quality control ranges. The in vitro susceptibilities of 1,096 bacterial isolates, representing 23 different species or phenotypic groups, were determined for torezolid, linezolid, cefotaxime, and levofloxacin using Clinical and Laboratory Standards Institute (CLSI) broth microdilution MICs, minimum bactericidal concentrations (MBCs), agar dilution, and disk diffusion testing methods. Torezolid was very active against the majority of Gram-positive strains, including methicillin-susceptible and -resistant Staphylococcus aureus (MIC(50) = 0.25 mu g/ml, MIC(90)