Third Report of t(19q)(13.4) in Mesenchymal Hamartoma of Liver with Comments on Link to Embryonal Sarcoma
Third Report of t(19q)(13.4) in Mesenchymal Hamartoma of Liver with Comments on Link to Embryonal Sarcoma
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肝脏间质错构瘤中 t(19q)(13.4) 的第三次报告以及与胚胎肉瘤关联的评论
DOI：
10.1007/s100249900060
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发表时间：
1998
影响因子：
1.9
通讯作者：
S. Soukup
中科院分区：
文献类型：
--
作者：
K. Bove;R. Blough;S. Soukup
摘要 我们报告了第三例已知的肝脏间质错构瘤 (MHL) 病例，其平衡易位涉及常见断点 19q13.4。常见的克隆染色体异常似乎是 MHL 的一个重要亚型的特征，其中一些可能是低度肿瘤。我们在肝脏胚胎肉瘤（ESL）治疗后样本中没有发现一致的核型异常。两名患者同时存在 MHL 和 ESL 的报告以及在两名 ESL 中检测到 19q 异常的报告似乎支持斯托克关于这两种罕见肝脏病变之间存在组织遗传学联系的假设。需要更多数据来阐明这种关系。 MHL 的病因可能是异质的，可能是发育障碍、破坏或肿瘤。
ABSTRACT We report the third known case of mesenchymal hamartoma of the liver (MHL) with a balanced translocation involving a common breakpoint, 19q13.4. A common clonal chromosome abnormality appears to characterize an important subset of MHL, some of which may be low-grade neoplasms. We found no consistent karyotype abnormality in a post-treatment sample of embryonal sarcoma of the liver (ESL). Reports of coexistent MHL and ESL in two patients and detection of 19q abnormalities in two ESLs appear to support Stocker's hypothesis of a histogenetic link between these two rare liver lesions. More data are needed to clarify this relationship. It is possible that MHLs are etiologically heterogenous and may be developmental disorders, disruptions, or neoplasms.
十六种人类横纹肌肉瘤的染色体分析。
影响因子：
11.2
作者：
Wang-Wuu,S;Soukup,S;Ballard,E;Gotwals,B;Lampkin,B
通讯作者：
Lampkin,B