Dehydroepiandrosterone Supplementation Combined with Whole-Body Vibration Training Affects Testosterone Level and Body Composition in Mice.
Dehydroepiandrosterone Supplementation Combined with Whole-Body Vibration Training Affects Testosterone Level and Body Composition in Mice.
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DOI：
10.7150/ijms.16132
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发表时间：
2016
影响因子：
3.6
通讯作者：
Tzeng YD
中科院分区：
文献类型：
--
作者：
Chen WC;Chen YM;Huang CC;Tzeng YD
脱氢表雄酮（DHEA）是最丰富的性类固醇，主要由肾上腺分泌，是运动员用于提高成绩的前体激素。全身振动（Whole-body vibration，WBV）是一种著名的轻阻力运动，通过自动适应振动平台的快速和重复振荡，这也是老年人简单方便的运动。然而，DHEA补充与WBV训练相结合对身体成分，运动表现和激素调节的潜在影响目前尚不清楚。本研究的目的是探讨补充脱氢表雄酮（DHEA）结合WBV训练对成年C57 BL/6小鼠体成分、运动能力、体力疲劳相关生化反应和睾酮含量的影响。在这项研究中，雄性C57 BL/6小鼠被分为四组（每组n = 8）进行6周治疗：久坐对照，补充溶媒（SC）、DHEA（DHEA，10.2 mg/kg），WBV训练（WBV; 5.6Hz，2 mm，0.13g）和补充DHEA的WBV训练（WBV+DHEA; WBV：5.6Hz，2 mm，0.13g和DHEA：10.2mg/kg）。运动能力评价指标包括前肢握力和力竭游泳时间，以及15 min游泳运动后机体组成和血清乳酸、血氨、葡萄糖、肌酸激酶（CK）、血尿素氮（BUN）的变化。实验结束时测定血清生化指标和睾酮含量。与SC组相比，6周单独补充DHEA显著增加小鼠体重（BW），肌肉重量，睾酮水平和糖原含量（肝脏和肌肉）。单独补充DHEA对所有组织和生化特征没有负面影响，但不能改善运动表现。但与单独补充DHEA相比，WBV+DHEA还显著降低了15 min游泳运动后体重、睾酮水平和肝糖原含量，以及血清乳酸和氨水平。虽然单独补充DHEA对小鼠的运动表现没有有益的影响，但体重、睾酮水平和糖原含量显著增加。另一方面，WBV训练结合DHEA降低了由补充DHEA引起的体重增长、睾酮水平和糖原含量。因此，WBV训练可抑制补充DHEA合成睾酮水平或降低DHEA补充剂的吸收能力。
Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear. The objective of the study is to investigate the effects of DHEA supplementation combined with WBV training on body composition, exercise performance, and physical fatigue-related biochemical responses and testosterone content in young-adult C57BL/6 mice. In this study, male C57BL/6 mice were divided into four groups (n = 8 per group) for 6-weeks treatment: sedentary controls with vehicle (SC), DHEA supplementation (DHEA, 10.2 mg/kg), WBV training (WBV; 5.6 Hz, 2 mm, 0.13 g), and WBV training with DHEA supplementation (WBV+DHEA; WBV: 5.6 Hz, 2 mm, 0.13 g and DHEA: 10.2 mg/kg). Exercise performance was evaluated by forelimb grip strength and exhaustive swimming time, as well as changes in body composition and anti-fatigue levels of serum lactate, ammonia, glucose, creatine kinase (CK), and blood urea nitrogen (BUN) after a 15-min swimming exercise. In addition, the biochemical parameters and the testosterone content were measured at the end of the experiment. Six-week DHEA supplementation alone significantly increased mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group. DHEA supplementation alone had no negative impact on all tissue and biochemical profiles, but could not improve exercise performance. However, WBV+DHEA supplementation also significantly decreased BW, testosterone level and glycogen content of liver, as well as serum lactate and ammonia levels after the 15-min swimming exercise when compared with DHEA supplementation alone. Although DHEA supplementation alone had no beneficial effect in the exercise performance of mice, the BW, testosterone level and glycogen content significantly increased. On the other hand, WBV training combined with DHEA decreased the BW gain, testosterone level and glycogen content caused by DHEA supplementation. Therefore, WBV training could inhibit DHEA supplementation to synthesis the testosterone level or may decrease the DHEA supplement absorptive capacity in young-adult mice.
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DOI：
10.1093/gerona/52a.1.m1
发表时间：
1997-01-01
影响因子：
5.1
作者：
Khorram, O;Vu, L;Yen, SSC
通讯作者：
Yen, SSC
影响因子：
6.1
作者：
Campbell, CSG;Caperuto, LC;Carvalho, CRO
通讯作者：
Carvalho, CRO
DOI：
10.1249/mss.0b013e3181f2589f
发表时间：
2011-03-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Coza, Aurel;Nigg, Benno M.;Dunn, Jeff F.
通讯作者：
Dunn, Jeff F.
影响因子：
4.1
作者：
Mikhael M;Orr R;Amsen F;Greene D;Singh MA
通讯作者：
Singh MA
影响因子：
5.4
作者：
Figueroa, Arturo;Gil, Ryan;Sanchez-Gonzalez, Marcos A.
通讯作者：
Sanchez-Gonzalez, Marcos A.