Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial.
Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial.
复制标题
通过局部施用米诺环素微球治疗牙周炎：一项对照试验。
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Lessem
中科院分区：
文献类型：
--
作者：
Ray Williams;D. Paquette;S. Offenbacher;Donald F. Adams;G. Armitage;K. Bray;J. Caton;D. Cochran;C. Drisko;J. Fiorellini;W. Giannobile;S. Grossi;Denise Guerrero;G. K. Johnson;I. Lamster;I. Magnusson;R. Oringer;G. R. Persson;T. Dyke;L. Wolff;E. Santucci;B. Rodda;J. Lessem
背景
牙周炎是牙齿支持组织的炎症性疾病，通常通过机械去除粘附在牙齿上的牙菌斑和微生物来治疗。这种治疗称为洗牙和根面平整，效果不佳。局部抗菌药物的辅助治疗改善了临床结果，例如探诊深度减少。本文报告了局部给药微囊米诺环素的功效和安全性。
方法
七百四十八 (748) 名患有中度至晚期牙周炎的患者参加了一项多中心试验，并随机分配至 3 个治疗组中的 1 个：1) 单纯刮治和根面平整 (SRP)； 2) SRP加车辆；或3) SRP加米诺环素微球。主要结果指标是 9 个月时探诊深度减少。在基线以及第 1、3、6 和 9 个月时进行临床评估。
结果
与单独的 SRP 或 SRP 加载体相比，米诺环素微球加上刮治和根面平整可显着减少探查深度。第一个月后差异达到统计学显着性，并在整个试验过程中保持不变。据观察，改善的结果与患者的吸烟状况、年龄、性别或基线疾病水平无关。治疗组之间的不良反应发生率没有差异。
结论
在减少牙周炎患者的探诊深度方面，洗牙和根面平整加米诺环素微球比单独洗牙和根面平整更有效。
BACKGROUND
Periodontitis is an inflammatory condition of tooth-supporting tissues that is usually treated by mechanical removal of plaque and microorganisms that adhere to teeth. This treatment, known as scaling and root planing, is not optimally effective. Adjunctive therapy with locally delivered antimicrobials has resulted in improved clinical outcomes such as probing depth reduction. This article reports on the efficacy and safety of locally administered microencapsulated minocycline.
METHODS
Seven hundred forty-eight (748) patients with moderate to advanced periodontitis were enrolled in a multi-center trial and randomized to 1 of 3 treatment arms: 1) scaling and root planing (SRP) alone; 2) SRP plus vehicle; or 3) SRP plus minocycline microspheres. The primary outcome measure was probing depth reduction at 9 months. Clinical assessments were performed at baseline and 1, 3, 6, and 9 months.
RESULTS
Minocycline microspheres plus scaling and root planing provided substantially more probing depth reduction than either SRP alone or SRP plus vehicle. The difference reached statistical significance after the first month and was maintained throughout the trial. The improved outcome was observed to be independent of patients' smoking status, age, gender, or baseline disease level. There was no difference in the incidence of adverse effects among treatment groups.
CONCLUSIONS
Scaling and root planing plus minocycline microspheres is more effective than scaling and root planing alone in reducing probing depths in periodontitis patients.
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影响因子：
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作者：
Wu, TJ;Trevisan, M;Sempos, CT
通讯作者：
Sempos, CT
DOI：
10.1902/annals.1998.3.1.51
发表时间：
1998-07-01
期刊：
Annals of periodontology
影响因子：
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作者：
Grossi, S G;Genco, R J
通讯作者：
Genco, R J
影响因子：
4.3
作者：
Grossi, SG;Skrepcinksi, FB;Genco, RJ
通讯作者：
Genco, RJ
DOI：
10.1902/annals.1998.3.1.233
发表时间：
1998-07-01
期刊：
Annals of periodontology
影响因子：
--
作者：
Offenbacher, S;Jared, H L;Beck, J D
通讯作者：
Beck, J D