Regional brain response patterns to Cheyne-Stokes breathing
Regional brain response patterns to Cheyne-Stokes breathing
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DOI：
10.1016/j.resp.2005.08.007
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发表时间：
2006-01-25
影响因子：
2.3
通讯作者：
Harper, RM
中科院分区：
文献类型：
--
作者：
Henderson, LA;Macey, KE;Harper, RM
Cheyne-Stokes呼吸（CSB）是由感觉信息与呼吸运动输出的整合受损引起的;然而，介导干扰控制的区域是未知的。我们检查了睡眠中CSB期间的功能性磁共振成像信号，以确定受影响的区域。两名男性患者严重阻塞性睡眠呼吸暂停扫描，而在多个会议期间，他们表现出CSB睡眠。显着的信号增加，同时出现在双侧小脑皮质，海马，丘脑背内侧，额叶皮质和中央前回的呼吸暂停期。信号在前扣带皮层和中央后回双侧下降。初级感觉皮层的激活减少和运动皮层中呼吸开始之前的信号增加与气流引起的感觉刺激的丧失以及呼吸开始之前运动皮层的预期作用一致。海马和前扣带皮层的参与可能反映了先前证明的启动吸气努力和解决感觉信息和运动动作的作用。(C)2005 Elsevier B. V.保留所有权利。
Cheyne-Stokes breathing (CSB) results from impaired integration of sensory information with respiratory motor output; however, regions mediating the disturbed control are unknown. We examined functional magnetic resonance imaging signals during CSB within sleep to determine affected areas. Two male patients with severe obstructive sleep apnea were scanned while asleep over multiple sessions during which they exhibited CSB.Significant signal increases coincident with apneic periods emerged bilaterally in the cerebellar cortex, hippocampus, mediodorsal thalamus, frontal cortex and precentral gyrus. Signals declined bilaterally in the anterior cingulate cortex and postcentral gyrus. The reduced activation in primary sensory cortex and increased signals prior to breathing onset in the motor cortex are consistent with loss of sensory stimulation by airflow, and with anticipatory action of the motor cortex prior to initiation of breathing. Hippocampal and anterior cingulate cortex participation likely reflect previously-demonstrated roles for initiating inspiratory efforts and resolving sensory information and motor action, respectively. (C) 2005 Elsevier B.V. All rights reserved.