Prevalence of and Risk Factors for Age-Related Macular Degeneration in a Multiethnic Asian Cohort
Prevalence of and Risk Factors for Age-Related Macular Degeneration in a Multiethnic Asian Cohort
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DOI：
10.1001/archophthalmol.2011.376
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发表时间：
2012-04-01
影响因子：
--
通讯作者：
Wong, Tien Y.
中科院分区：
文献类型：
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作者：
Cheung, Chui Ming Gemmy;Tai, E. Shyong;Wong, Tien Y.
目的：描述年龄相关性黄斑变性（AMD）的患病率和危险因素在多种族亚洲队列的中国人，马来人，和Indian persons.Methods：在这项以人群为基础的研究中，3172人的中国人，马来人，和印度种族40岁及以上。参与者接受了全面的全身和眼部检查，视网膜摄影和实验室检查。根据视网膜照片对早期和晚期AMD体征进行分级。使用2010年新加坡成人人口作为标准人口计算了标准化患病率估计值。与一系列系统性危险因素的关联进行了analysed.Results：3172名参与者，AMD是目前在211名受试者。40岁及以上人群中AMD的年龄标准化患病率为7.0%。年龄标准化患病率在所有3个亚洲种族中相似：华人，7.3%;马来人，7.7%;印度人，5.7%（P值= 0.44）。患病率随着年龄的增长而增加，男性患病率更高。在评估的风险因素中，只有近视屈光不正（
Objective: To describe the prevalence of and risk factors for age-related macular degeneration (AMD) in a multiethnic Asian cohort of Chinese, Malay, and Indian persons.Methods: In this population-based study, 3172 persons of Chinese, Malay, and Indian ethnicities 40 years and older were included. Participants underwent comprehensive systemic and ocular examination, retinal photography, and laboratory investigations. Early and late AMD signs were graded from retinal photographs. Age-standardized prevalence estimates were calculated using the 2010 Singapore adult population as the standard population. Association with a range of systemic risk factors was analyzed.Results: Of 3172 participants, AMD was present in 211 subjects. Age-standardized prevalence of AMD was 7.0% in persons 40 years and older. The age-standardized prevalence was similar in all 3 Asian ethnic groups: Chinese, 7.3%; Malay, 7.7%; and Indian, 5.7% (P value=.44). The prevalence increased with age and was higher in men. Of the range of risk factors evaluated, only myopic refractive error (