Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation
Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation
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DOI：
10.1006/taap.1998.8472
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发表时间：
1998-08-01
影响因子：
3.8
通讯作者：
Thevenaz, P
中科院分区：
文献类型：
--
作者：
Hesterberg, TW;Chase, G;Thevenaz, P
纤维生物持久性作为纤维诱导致病性的主要机制进行了研究。采用大鼠吸入模型，评价了5种合成玻璃纤维（SVFs）和铁石棉的肺生物持久性。与之前的几项研究相反，本研究检查了在pH 7.4下体外溶解相对缓慢的纤维。Fisher大鼠通过仅鼻吸入暴露于耐火陶瓷纤维（RCF 1a）、石（石）棉（MMVF 21）、2种相对耐用的特殊应用纤维玻璃（MMVF 32或MMVF 33）、HT石棉（MMVF 34）、铁石棉或过滤空气5天。在暴露后1年内分析肺负荷。纤维气溶胶含有150-230根纤维/cc，长度大于20 μ m（>20 μ m）。在暴露后第1天，6种试验纤维的长纤维肺负荷相似（12-16 x 10（5）纤维/肺>20 μ m）。1年后，SVF肺中残留的>20 Ccm纤维百分比为0.04-10%，而铁石棉为27%。对于纤维>20 μ m，MMVF 34的肺清除加权半衰期（WT 1/2）为6天，其他4种SVF为50-80天，铁石棉>400天。这项研究和3个以前的研究表明，广泛的生物持久性为19个不同的SVF和2石棉类型。这些纤维中有10种也已经（或正在）在慢性吸入研究中进行了测试;在这些研究中，非常具有生物持久性的纤维具有致癌性（铁石棉、青石棉、RCF 1、MMVF 32和MMVF 33），而更快速清除的纤维则没有致癌性（MMVF 10、11、21、22和34）。这些研究证明了生物持久性作为广泛纤维类型潜在致病性的指标的重要性。(C)北京：科学出版社.
Fiber biopersistence as a major mechanism of fiber-induced pathogenicity was investigated. The lung biopersistence of 5 synthetic vitreous fibers (SVFs) and amosite asbestos was evaluated using the rat inhalation model. In contrast to several previous studies, this study examined fibers that dissolve relatively slowly in vitro at pH 7.4. Fisher rats were exposed for 5 days by nose-only inhalation to refractory ceramic fiber (RCF1a), rock (stone) wool (MMVF21), 2 relatively durable special application fiber glasses (MMVF32 or MMVF33), HT stonewool (MMVF34), amosite asbestos, or filtered air. Lung burdens were analyzed during 1 year post-exposure. Fiber aerosols contained 150-230 fibers/cc longer than 20 mu m (>20 mu m). On post-exposure Day 1, long-fiber lung burdens for the 6 test fibers were similar (12-16 x 10(5) fibers/lung >20 mu m). After I year, the percentage of fibers >20 Ccm remaining in the lung was 0.04-10% for SVFs but 27% for amosite. Lung clearance weighted half-times (WT1/2) for fibers >20 mu m were 6 days for MMVF34, 50-80 days for the other 4 SVFs, and >400 days for amosite. This study and 3 previous studies demonstrate a broad range of biopersistences for 19 different SVFs and 2 asbestos types. Ten of these fibers also have been (or are being) tested in chronic inhalation studies; in these studies, the very biopersistent fibers were carcinogenic (amosite, crocidolite, RCF1, MMVF32, and MMVF33), while the more rapidly clearing fibers were not (MMVF10, 11, 21, 22, and 34). These studies demonstrate the importance of biopersistence as an indicator of the potential pathogenicity of a wide range of fiber types. (C) 1998 Academic Press.