A geographic history of human genetic ancestry.
A geographic history of human genetic ancestry.
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人类遗传祖先的地理历史。
DOI：
10.1101/2024.03.27.586858
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Bradburd,GideonS
中科院分区：
文献类型：
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作者：
Grundler,MichaelC;Terhorst,Jonathan;Bradburd,GideonS
描述遗传变异在个体间的分布是群体遗传学的一个基本目标。我们提出了一种方法，利用基因组树序列中编码的丰富家谱信息来推断测序个体样本的共同祖先的地理位置。我们使用这种方法来推断一组来自欧洲、亚洲和非洲的人类基因组的遗传祖先的地理历史，准确地恢复了这些大陆上的主要人口流动。我们的研究结果表明，在描述人类遗传变异时，定义遗传祖先的时空背景是非常重要的，并且要警惕当代种族和祖先讨论中普遍存在的对遗传数据的过度简化解释。
Describing the distribution of genetic variation across individuals is a fundamental goal of population genetics. We present a method that capitalizes on the rich genealogical information encoded in genomic tree sequences to infer the geographic locations of the shared ancestors of a sample of sequenced individuals. We used this method to infer the geographic history of genetic ancestry of a set of human genomes sampled from Europe, Asia, and Africa, accurately recovering major population movements on those continents. Our findings demonstrate the importance of defining the spatiotemporal context of genetic ancestry when describing human genetic variation and caution against the oversimplified interpretations of genetic data prevalent in contemporary discussions of race and ancestry.