Association Between Depression and the Gln460Arg Polymorphism of P2RX7 Gene: A Dimensional Approach
Association Between Depression and the Gln460Arg Polymorphism of P2RX7 Gene: A Dimensional Approach
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DOI：
10.1002/ajmg.b.30799
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发表时间：
2009-03-05
影响因子：
2.8
通讯作者：
Nemoda, Zsofia
中科院分区：
文献类型：
--
作者：
Hejjas, Krisvina;Szekely, Anna;Nemoda, Zsofia
P2RX7基因（编码P2X7嘌呤能受体）被认为是重度抑郁症（MDD）和双相情感障碍（BIRD）的一个新的候选基因。rs2230912多态性的风险等位基因（g等位基因）导致第460位氨基酸发生变化，表明该遗传变异可能是功能性变异。在这里，我们对171名诊断为重度抑郁症或BPD的患者和178名对照组进行了病例对照分析，并使用医院焦虑和抑郁量表（HADS）研究了P2RX7基因Gln460Arg多态性作为抑郁症的遗传风险因素。虽然病例对照分析未显示组间差异显著，但临床组P2RX7多态性与HADS量表之间存在显著相关性（方差分析P = 0.001）。在基因型组中，焦虑和抑郁评分随g等位基因数量的增加而增加（hads -焦虑的方差分析：P < 0.01， hads -抑郁的方差分析：P < 0.001）。临床状态与P2RX7多态性在抑郁量表中也存在显著的相互作用（方差分析P = 0.025，随后方差分析焦虑量表：P = 0.252，抑郁量表：P = 0.002）。存在g等位基因型的患者抑郁得分更高，而对照组的抑郁水平不受P2RX7基因型的影响。总之，病例对照分析没有显示出显著的结果，但使用症状严重程度量表，我们可以支持抑郁症与P2RX7基因Gln460Arg多态性的g等位基因之间的关联。(C) 2008 Wiley-Liss, Inc。
The P2RX7 gene (coding for P2X7 purinergic receptor) has been Suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BIRD). The proposed risk allele (G-allele) of the rs2230912 polymorphism results in an amino acid change at the 460th position, marking this genetic variation a possibly functional one. Here we present a case-control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression. While case-control analysis did not show significant difference between the groups, a significant association was found between the P2RX7 polymorphism and the HADS scales in the clinical group (MANOVA P = 0.001). Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P 0.01, HADS-depression: P < 0.001). A significant interaction of clinical status and the P2RX7 polymorphism was also found for the depression scale (MANOVA P - 0.025, subsequent ANOVA for anxiety: P = 0.252; depression: P = 0.002). Whereas patients with G-allele-present genotypes showed more elevated depression scores, level of depression in the control group was not affected by the P2RX7 genotype. In conclusion, case-control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene. (C) 2008 Wiley-Liss, Inc.