Leishmania donovani Infection of a Susceptible Host Results in CD4+ T‐Cell Apoptosis and Decreased Th1 Cytokine Production
Leishmania donovani Infection of a Susceptible Host Results in CD4+ T‐Cell Apoptosis and Decreased Th1 Cytokine Production
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易感宿主的杜氏利什曼原虫感染导致 CD4+ T 细胞凋亡和 Th1 细胞因子产生减少
DOI：
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发表时间：
1999
影响因子：
3.7
通讯作者：
G. C. Mishra
中科院分区：
文献类型：
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作者：
G. Das;H. Vohra;Kanury Rao;Bhaskar Saha;G. C. Mishra
内脏利什曼病是由原生动物寄生虫杜氏利什曼原虫引起的，其特征是细胞介导的免疫功能(CMI)受到抑制，寄生虫在易感宿主中生长不受阻碍。在抗性寄主中观察到相反的趋势。然而，在进展性疾病过程中这种CMI丢失的机制尚不清楚。在这份报告中，我们证明了来自易感宿主的40%以上的CD_4+T_ 细胞发生了凋亡，导致IL-2和干扰素-γ的分泌显著减少，而IL-4的分泌没有受到影响。这些变化在来自耐药宿主的cd4+T 细胞的情况下并不明显。本文报道的数据表明，实验性杜氏利什曼原虫感染导致敏感但不耐药宿主中分泌IL-2和干扰素-γ的细胞选择性缺失，而不是Th2型细胞。
The disease visceral leishmaniasis is caused by a protozoan parasite, Leishmania donovani and is characterized by depressed cell‐mediated immunity (CMI) and unhindered parasite growth in a susceptible host. The opposite trend is observed in a resistant host. However, the mechanism of this loss of CMI during the progressive disease is unknown as yet. In this report, we demonstrate that more than 40% of CD4+ T cells from a susceptible host undergo apoptosis resulting in a significant decrease in interleukin (IL)‐2 and interferon (IFN)‐γ secretion, leaving IL‐4 secretion unaffected. These changes are not apparent in the case of CD4+ T cells derived from a resistant host. The data reported here suggest that experimental Leishmania donovani infection leads to selective deletion of the IL‐2 and IFN‐γ‐secreting cells but not Th2‐like cells in a susceptible but not a resistant host.
阻断 CD28-B7 对实验性利什曼病中 Th1 或 Th2 效应细胞发育的不同影响。
DOI：
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发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Corry,DB;Reiner,SL;Linsley,PS;Locksley,RM
通讯作者：
Locksley,RM
影响因子：
4.4
作者：
GREEN, SJ;SCHELLER, LF;NACY, CA
通讯作者：
NACY, CA