Effects of nutritional measures on toenail arsenic concentration as a biomarker of arsenic exposure.
Effects of nutritional measures on toenail arsenic concentration as a biomarker of arsenic exposure.
复制标题
营养措施对脚趾甲砷浓度作为砷暴露生物标志物的影响。
DOI：
10.1080/13547500802029050
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Nriagu,JeromeO
中科院分区：
文献类型：
--
作者：
Slotnick,MelissaJ;Meliker,JaymieR;Kannan,Srimathi;Nriagu,JeromeO
饮用水和脚趾甲砷浓度之间的相关性已在先前的研究中得到证实，但可能改变暴露-生物标志物关联的因素尚未得到充分评估。使用美国密歇根州正在进行的一项膀胱癌研究的500名对照者的数据，评估了人口统计学特征和营养措施对生物标志物反应的影响。在家访期间收集了饮用水和脚趾甲样本，并分析了砷和其他元素。参与者报告了膳食补充剂的摄入习惯，并提供了人口统计数据。饮用水砷浓度与脚趾甲样品呈正相关。在评估的营养指标中，趾甲铁浓度是暴露-生物标志物关联的重要修饰因子。没有人口统计学特征或饮食摄入的一般测量影响生物标志物反应。本文的结果对生物标志物的验证至关重要，并证明了砷趾甲生物标志物在未来流行病学调查中的良好应用前景。
Correlations between drinking water and toenail arsenic concentrations have been demonstrated in previous studies, yet factors that may modify the exposure–biomarker association have not been adequately assessed. Using data from 500 controls enrolled in a bladder cancer study underway in Michigan, USA, the effects of demographic characteristics and nutritional measures on the biomarker response were evaluated. Drinking water and toenail samples were collected during a home visit and analyzed for arsenic and other elements. Participants reported dietary supplement intake habits and provided demographic data. Arsenic concentrations of drinking water and toenail samples were positively correlated. Of the nutritional measures evaluated, toenail iron concentration was a significant modifier of the exposure–biomarker association. No demographic characteristics or general measures of dietary intake affected the biomarker response. The results presented herein are critical for biomarker validation and prove promising for sound application of the arsenic toenail biomarker to future epidemiological investigations.